Copper in mammals: mechanisms of homeostasis and pathophysiology

Cater, Michael A. and Mercer, Julian 2006, Copper in mammals: mechanisms of homeostasis and pathophysiology. In Tamás, Markus J. and Martinoia, Enrico (ed), Molecular biology of metal homeostasis and detoxification : from microbes to man, Springer-Verlag, Berlin, Germany, pp.101-120, doi: 10.1007/4735_101.

Attached Files
Name Description MIMEType Size Downloads

Title Copper in mammals: mechanisms of homeostasis and pathophysiology
Author(s) Cater, Michael A.
Mercer, Julian
Title of book Molecular biology of metal homeostasis and detoxification : from microbes to man
Editor(s) Tamás, Markus J.
Martinoia, Enrico
Publication date 2006
Series Topics in current genetics ; v. 14
Chapter number 3
Total chapters 14
Start page 101
End page 120
Total pages 20
Publisher Springer-Verlag
Place of Publication Berlin, Germany
Keyword(s) homeostasis
copper
Summary The ability of mammals to tightly regulate systemic copper levels is vital for
health as demonstrated by the severity of the genetic copper deficiency and copper toxicity disorders, Menkes disease and Wilson disease, respectively. Analysis of these genetic disorders has led to a substantial increase in the understanding of the role of copper in health and disease. The isolation of the genes involved in these diseases and use of yeast mutants with altered copper and iron homeostasis has revealed a range of molecular mechanisms governing copper homeostasis. These mechanisms include regulation of cellular copper uptake and efflux and involve the use of chaperones for safe intracellular copper distribution. Here we provide an overview of the physiological role of copper and the molecular mechanisms
regulating systemic and cellular copper levels in mammals. Furthermore, we discuss the pathophysiological mechanisms and consequences of copper deficiency/overload in relation to disease.
ISBN 3540221751
9783540221753
ISSN 1610-6970
1610-2096
Language eng
DOI 10.1007/4735_101
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category B1 Book chapter
Copyright notice ©2005 Springer-Verlag Berlin Heidelberg
Persistent URL http://hdl.handle.net/10536/DRO/DU:30000801

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 7 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 1020 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Thu, 03 Jul 2008, 11:12:58 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.