Copper in mammals: mechanisms of homeostasis and pathophysiology

Cater, Michael A. and Mercer, Julian 2006, Copper in mammals: mechanisms of homeostasis and pathophysiology. In Tamás, Markus J. and Martinoia, Enrico (ed), Molecular biology of metal homeostasis and detoxification : from microbes to man, Springer-Verlag, Berlin, Germany, pp.101-120, doi: 10.1007/4735_101.

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Title Copper in mammals: mechanisms of homeostasis and pathophysiology
Author(s) Cater, Michael A.
Mercer, Julian
Title of book Molecular biology of metal homeostasis and detoxification : from microbes to man
Editor(s) Tamás, Markus J.
Martinoia, Enrico
Publication date 2006
Series Topics in current genetics ; v. 14
Chapter number 3
Total chapters 14
Start page 101
End page 120
Total pages 20
Publisher Springer-Verlag
Place of Publication Berlin, Germany
Keyword(s) homeostasis
Summary The ability of mammals to tightly regulate systemic copper levels is vital for
health as demonstrated by the severity of the genetic copper deficiency and copper toxicity disorders, Menkes disease and Wilson disease, respectively. Analysis of these genetic disorders has led to a substantial increase in the understanding of the role of copper in health and disease. The isolation of the genes involved in these diseases and use of yeast mutants with altered copper and iron homeostasis has revealed a range of molecular mechanisms governing copper homeostasis. These mechanisms include regulation of cellular copper uptake and efflux and involve the use of chaperones for safe intracellular copper distribution. Here we provide an overview of the physiological role of copper and the molecular mechanisms
regulating systemic and cellular copper levels in mammals. Furthermore, we discuss the pathophysiological mechanisms and consequences of copper deficiency/overload in relation to disease.
ISBN 3540221751
ISSN 1610-6970
Language eng
DOI 10.1007/4735_101
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category B1 Book chapter
Copyright notice ©2005 Springer-Verlag Berlin Heidelberg
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