Association of birth weight and current body size to blood pressure in female twins

Nowson, Caryl, MacInnis, Robert J., Hopper, John L., Alexander, Jo L., Paton, Lynda M., Margerison, Claire and Wark, John D. 2001, Association of birth weight and current body size to blood pressure in female twins, Twin research, vol. 4, no. 5, pp. 378-384, doi: 10.1375/1369052012551.

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Title Association of birth weight and current body size to blood pressure in female twins
Author(s) Nowson, CarylORCID iD for Nowson, Caryl
MacInnis, Robert J.
Hopper, John L.
Alexander, Jo L.
Paton, Lynda M.
Margerison, ClaireORCID iD for Margerison, Claire
Wark, John D.
Journal name Twin research
Volume number 4
Issue number 5
Start page 378
End page 384
Publisher Australian Academic Press
Place of publication Bowen Hills, Qld.
Publication date 2001-10-01
ISSN 1369-0523
Summary It has been proposed that low birth weight is associated with high levels of blood pressure in later life. The aim of this study was to assess the relationship of blood pressure to birth weight and current body size during growth and adulthood. A total of 711 female multiple births, with one group of 244 in their growth phase mean age 12.0 (2.3)(SD) years and the other of 467 adults (mean age 35.2 (12.6) years), had height, weight and both systolic (SBP) and diastolic (DBP) blood pressures measured, and self-reported their birth weight. Regression analyses were performed to assess the cross-sectional and within-pair associations of blood pressure to birth weight, with and without adjustments for current body size. Within-pair analysis was based on 296 twin pairs. Cross-sectionally, a reduction in birth weight of 1 kg was associated with 2 to 3 mm Hg higher age-adjusted SBP, which was of marginal significance and explained about 2% of the population variance. Adjustment for body mass index did not significantly change this association. Within-pair analyses found no association between birth weight and SBP or DBP,even after adjusting for current body size. After age, current body size was the strongest predictor of systolic BP. The weak association of blood pressure to birth weight cross-sectionally is of interest, but any within-pair effect of birth weight on blood pressure must be minimal compared with the effect of current body size.

Language eng
DOI 10.1375/1369052012551
Field of Research 111706 Epidemiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, Australian Academic Press
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