Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats)
Walder, Ken, McMillan, Janine, Lee, Scott, Civitarese, Anthony, Zimmet, Paul and Collier, Gregory 2001, Effects of beacon administration on energy expenditure and substrate utilisation in Psammomys obesus (Israeli sand rats), International journal of obesity, vol. 25, no. 9, pp. 1281-1285.
(Some files may be inaccessible until you login with your DRO credentials)
Objective: To investigate whether beacon administration affects substrate utilisation, physical activity levels or energy expenditure in Psammomysobesus. Design: Pairs of age- and sex-matched Psammomys obesus were randomly assigned to either beacon-treated (15 µg/day for 7 days (i.c.v.)) or control (i.c.v. saline) groups. Measurements: Indirect calorimetry on day 0 and day 7 to measure oxygen consumption and carbon dioxide production, which were used to calculate fat oxidation, carbohydrate oxidation and total energy expenditure. Physical activity in the calorimeter was measured using an infrared beam system. Food intake and body weight were measured daily. Results: The administration of beacon significantly increased body weight compared to saline-treated control animals. This body weight gain was primarily due to increased body fat content. Average daily food intake tended to be higher in beacon-treated Psammomys obesus, but no effect of beacon administration on substrate oxidation, activity or energy expenditure was detected. Conclusion: The effects of beacon on body weight are due to increased food intake, with no detectable effect on nutrient partitioning, physical activity or energy expenditure.
Field of Research
111716 Preventive Medicine
Socio Economic Objective
970111 Expanding Knowledge in the Medical and Health Sciences
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO.
If you believe that your rights have been infringed by this repository, please contact email@example.com.