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ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells

Gregorio-King,C, Collier,G, McMillan,J, Waugh,C, McLeod,J, Collier,F and Kirkland,M 2001, ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells, Blood, vol. 98, no. 7, pp. 2279-2281, doi: 10.1182/blood.V98.7.2279.

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Title ORP-3, a human oxysterol-binding protein gene differentially expressed in hematopoietic cells
Author(s) Gregorio-King,C
Collier,G
McMillan,J
Waugh,C
McLeod,J
Collier,F
Kirkland,M
Journal name Blood
Volume number 98
Issue number 7
Start page 2279
End page 2281
Total pages 3
Publisher American Society of Hematology
Place of publication Washington, D.C.
Publication date 2001-10-01
ISSN 0006-4971
1528-0020
Keyword(s) Science & Technology
Life Sciences & Biomedicine
Hematology
PLECKSTRIN HOMOLOGY DOMAIN
STEM-CELLS
LEUCINE ZIPPER
CHOLESTEROL
IDENTIFICATION
METABOLISM
RECEPTOR
CYCLE
BLOOD
OSBP
Summary Using differential display polymerase chain reaction, a gene was identified in CD34+-enriched populations that had with low or absent expression in CD34- populations. The full coding sequence of this transcript was obtained, and the predicted protein has a high degree of homology to oxysterol-binding protein. This gene has been designated OSBP-related protein 3 (ORP-3). Expression of ORP-3 was found to be 3- to 4-fold higher in CD34+ cells than in CD34- cells. Additionally, expression of this gene was 2-fold higher in the more primitive subfraction of hematopoietic cells defined by the CD34+38- phenotype and was down-regulated with the proliferation and differentiation of CD34+ cells. The ORP-3 predicted protein contains an oxysterol-binding domain. Well-characterized proteins expressing this domain bind oxysterols in a dose-dependent fashion. Biologic activities of oxysterols include inhibition of cholesterol biosynthesis and cell proliferation in a variety of cell types, among them hematopoietic cells. Characterization and differential expression of ORP-3 implicates a possible role in the mediation of oxysterol effects on hematopoiesis.
Language eng
DOI 10.1182/blood.V98.7.2279
Field of Research 111716 Preventive Medicine
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, American Society of Hematology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001173

Document type: Journal Article
Collection: School of Health Sciences
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