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Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus

Minerds, K. L. and Donald, John 2001, Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus, Comparative biochemistry and physiology - part a: molecular & integrative physiology, vol. 128, no. 2, pp. 259-268, doi: 10.1016/S1095-6433(00)00302-0.

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Title Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus
Formatted title Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus
Author(s) Minerds, K. L.
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Journal name Comparative biochemistry and physiology - part a: molecular & integrative physiology
Volume number 128
Issue number 2
Start page 259
End page 268
Publisher Elsevier Science Inc.
Place of publication New York, N. Y.
Publication date 2001
ISSN 1095-6433
1531-4332
Keyword(s) atrial natriuretic peptide
blood vessels
clearance receptors
guanylyl cyclase
cGMP
natriuretic peptide receptors
c-type natriuretic peptide
Bufo marinus
Summary Natriuretic peptide receptors in the central vasculature of the toad, Bufo marinus, were characterized using autoradiographical, molecular, and physiological techniques. Specific 125I-rat ANP binding sites were present in the carotid and pulmonary arteries, the lateral aorta, the pre- and post-cava, and the jugular vein, and generally occurred in each layer of the blood vessel. The 125I-rat ANP binding was partially displaced by the specific natriuretic peptide receptor C ligand, C-ANF, which indicates the presence of two types of natriuretic peptide receptors in the blood vessels. This was confirmed by a RT-PCR study, which demonstrated that guanylyl cyclase receptor (NPR-GC) and NPR-C mRNAs are expressed in arteries and veins. An in vitro guanylyl cyclase assay showed that frog ANP stimulated the production of cGMP in arterial membrane fractions. Physiological recordings from isolated segments of the carotid and pulmonary arteries and the lateral aorta, which had been pre-constricted with arginine vasotocin, showed that rat ANP, frog ANP and porcine CNP relaxed the vascular smooth muscle with relatively similar potency. Together, the data show that the central vasculature contains two types of natriuretic peptide receptors (NPR-C and NPR-GC) and that the vasculature is a target for ANP and CNP.
Language eng
DOI 10.1016/S1095-6433(00)00302-0
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2001, Elsevier Science Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001284

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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