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Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes

Walder, Ken, Ziv, E., Kalman, R., Whitecross, K., Shafrir, E., Zimmet, Paul and Collier, Gregory 2002, Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes, International journal of obesity, vol. 26, no. 5, pp. 605-609.

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Title Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes
Author(s) Walder, Ken
Ziv, E.
Kalman, R.
Whitecross, K.
Shafrir, E.
Zimmet, Paul
Collier, Gregory
Journal name International journal of obesity
Volume number 26
Issue number 5
Start page 605
End page 609
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2002-05
ISSN 0307-0565
1476-5497
Keyword(s) beacon gene
Psammomys obesus
obesity
hypothalamus
gene expression
Summary Objective: To investigate hypothalamic beacon gene expression at various developmental stages in genetically selected diabetes-resistant and diabetes-prone Psammomys obesus. In addition, effects of dietary energy composition on beacon gene expression were investigated in diabetes-prone P. obesus. Methods: Hypothalamic beacon gene expression was measured using TaqmanÔ fluorogenic PCR in 4-, 8- and 16-week-old animals from each genetically selected line. Results: Expression of beacon was elevated in the diabetes-prone compared with diabetes-resistant P. obesus at 4 weeks of age despite no difference in body weight between the groups. At 8 weeks of age, hypothalamic beacon gene expression was elevated in diabetes-prone animals fed a high-energy diet, and was correlated with serum insulin concentration. Conclusion: P. obesus with a genetic predisposition for the development of obesity and type 2 diabetes have elevated hypothalamic beacon gene expression at an early age. Overexpression of beacon may contribute to the development of obesity and insulin resistance in these animals.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001598

Document type: Journal Article
Collections: School of Health Sciences
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Created: Mon, 07 Jul 2008, 08:01:24 EST