Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes
Walder, Ken, Ziv, E., Kalman, R., Whitecross, K., Shafrir, E., Zimmet, Paul and Collier, Gregory 2002, Elevated hypothalamic beacon gene expression in Psammomys obesus prone to develop obesity and type 2 diabetes, International journal of obesity, vol. 26, no. 5, pp. 605-609.
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Objective: To investigate hypothalamic beacon gene expression at various developmental stages in genetically selected diabetes-resistant and diabetes-prone Psammomys obesus. In addition, effects of dietary energy composition on beacon gene expression were investigated in diabetes-prone P. obesus. Methods: Hypothalamic beacon gene expression was measured using TaqmanÔ fluorogenic PCR in 4-, 8- and 16-week-old animals from each genetically selected line. Results: Expression of beacon was elevated in the diabetes-prone compared with diabetes-resistant P.obesus at 4 weeks of age despite no difference in body weight between the groups. At 8 weeks of age, hypothalamic beacon gene expression was elevated in diabetes-prone animals fed a high-energy diet, and was correlated with serum insulin concentration. Conclusion: P. obesus with a genetic predisposition for the development of obesity and type 2 diabetes have elevated hypothalamic beacon gene expression at an early age. Overexpression of beacon may contribute to the development of obesity and insulin resistance in these animals.
Field of Research
060405 Gene Expression (incl Microarray and other genome-wide approaches)
Socio Economic Objective
970106 Expanding Knowledge in the Biological Sciences
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