New approaches to gene discovery with animal models of obesity and diabetes

Collier, Greg, Walder, Ken, De Silva, Andrea, Tenne-Brown, Janette, Sanigorski, Andrew, Segal, David, Kantham, Lakshmi and Augert, Guy 2002, New approaches to gene discovery with animal models of obesity and diabetes, Annals of the New York academy of science, vol. 967, no. Fourth International Meeting on Lipins and insulin resistance : the role of fatty acid metabolism and fuel partitioning, pp. 403-413.

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Title New approaches to gene discovery with animal models of obesity and diabetes
Author(s) Collier, Greg
Walder, Ken
De Silva, Andrea
Tenne-Brown, Janette
Sanigorski, Andrew
Segal, David
Kantham, Lakshmi
Augert, Guy
Journal name Annals of the New York academy of science
Volume number 967
Issue number Fourth International Meeting on Lipins and insulin resistance : the role of fatty acid metabolism and fuel partitioning
Start page 403
End page 413
Publisher New York Academy of Sciences
Place of publication New York, N.Y.
Publication date 2002
ISSN 0077-8923
1749-6632
Keyword(s) animal model of obesity and diabetes
RNA approaches to gene discovery
gene discovery
Summary DNA-based approaches to the discovery of genes contributing to the development of type 2 diabetes have not been very successful despite substantial investments of time and money. The multiple gene-gene and gene-environment interactions that influence the development of type 2 diabetes mean that DNA approaches are not the ideal tool for defining the etiology of this complex disease. Gene expression-based technologies may prove to be a more rewarding strategy to identify diabetes candidate genes. There are a number of RNA-based technologies available to identify genes that are differentially expressed in various tissues in type 2 diabetes. These include differential display polymerase chain reaction (ddPCR), suppression subtractive hybridization (SSH), and cDNA microarrays. The power of new technologies to detect differential gene expression is ideally suited to studies utilizing appropriate animal models of human disease. We have shown that the gene expression approach, in combination with an excellent animal model such as the Israeli sand rat (Psammomys obesus), can provide novel genes and pathways that may be important in the disease process and provide novel therapeutic approaches. This paper will describe a new gene discovery, beacon, a novel gene linked with energy intake. As the functional characterization of novel genes discovered in our laboratory using this approach continues, it is anticipated that we will soon be able to compile a definitive list of genes that are important in the development of obesity and type 2 diabetes.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, Wiley-Blackwell Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001601

Document type: Journal Article
Collection: School of Health Sciences
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