Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle

Tunstall, Rebecca, Mehan, Kate, Hargreaves, Mark, Spriet, Lawrence and Cameron-Smith, David 2002, Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle, Biochemical and biophysical research communications, vol. 294, no. 2, pp. 301-308.

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Title Fasting activates the gene expression of UCP3 independent of genes necessary for lipid transport and oxidation in skeletal muscle
Author(s) Tunstall, Rebecca
Mehan, Kate
Hargreaves, Mark
Spriet, Lawrence
Cameron-Smith, David
Journal name Biochemical and biophysical research communications
Volume number 294
Issue number 2
Start page 301
End page 308
Publisher Academic Press
Place of publication San Diego, Calif.
Publication date 2002-06
ISSN 0006-291X
1090-2104
Keyword(s) mRNA
diet–gene interaction
fatty acids
transcription factors
humans
fuel metabolism
Summary Fasting triggers a complex array of adaptive metabolic and hormonal responses including an augmentation in the capacity for mitochondrial fatty acid (FA) oxidation in skeletal muscle. This study hypothesized that this adaptive response is mediated by increased mRNA of key genes central to the regulation of fat oxidation in human skeletal muscle. Fasting dramatically increased UCP3 gene expression, by 5-fold at 15 h and 10-fold at 40 h. However the expression of key genes responsible for the uptake, transport, oxidation, and re-esterification of FA remained unchanged following 15 and 40 h of fasting. Likewise there was no change in the mRNA abundance of transcription factors. This suggests a unique role for UCP3 in the regulation of FA homeostasis during fasting as adaptation to 40 h of fasting does not require alterations in the expression of other genes necessary for lipid metabolism.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, Elsevier Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001610

Document type: Journal Article
Collection: School of Health Sciences
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