Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus
Sanigorski, Andrew, Fahey, Richard, Cameron-Smith, David and Collier, Gregory 2002, Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus, Diabetes, obesity and metabolism, vol. 4, no. 5, pp. 346-350.
(Some files may be inaccessible until you login with your Deakin Research Online credentials)
It has been reported previously that leptin may be involved in nicotine's ability to reduce body weight. Our aim was to investigate whether the anorexic action of nicotine is related to the actions of leptin by utilizing lean leptin-sensitive and obese leptin-resistant Psammomys obesus. Lean and obese P. obesus were assigned to receive nicotine sulphate at 6, 9 or 12 mg/day or saline (control) for 9 days (n = 6-10 in each group), administered using mini-osmotic pumps. Food intake, body weight, plasma leptin concentrations, plasma insulin and blood glucose were measured at baseline and throughout the study period. Nicotine treatment reduced food intake by up to 40% in lean and obese P. obesus. Plasma leptin levels fell significantly only in lean nicotine-treated animals, whereas no changes were observed in obese nicotine-treated animals. However, both lean and obese nicotine-treated animals had similar reductions in body weight. Our results show that nicotine has dramatic effects on food intake and body weight, however, these changes appear to be independent of the leptin signalling pathway.
The definitive version is available at www.blackwell-synergy.com
Field of Research
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Unless expressly stated otherwise, the copyright for items in Deakin Research Online is owned by the author, with all rights reserved.
Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO.
If you believe that your rights have been infringed by this repository, please contact email@example.com.