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Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus

Sanigorski, Andrew, Fahey, Richard, Cameron-Smith, David and Collier, Gregory 2002, Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus, Diabetes, obesity and metabolism, vol. 4, no. 5, pp. 346-350.

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Title Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus
Formatted title Nicotine treatment decreases food intake and body weight via a leptin-independent pathway in Psammomys obesus
Author(s) Sanigorski, Andrew
Fahey, Richard
Cameron-Smith, David
Collier, Gregory
Journal name Diabetes, obesity and metabolism
Volume number 4
Issue number 5
Start page 346
End page 350
Publisher Blackwell
Place of publication Oxford, England
Publication date 2002-09
ISSN 1462-8902
Keyword(s) nicotine
Isreal sand rat
leptin
obesity
Summary It has been reported previously that leptin may be involved in nicotine's ability to reduce body weight. Our aim was to investigate whether the anorexic action of nicotine is related to the actions of leptin by utilizing lean leptin-sensitive and obese leptin-resistant Psammomys obesus. Lean and obese P. obesus were assigned to receive nicotine sulphate at 6, 9 or 12 mg/day or saline (control) for 9 days (n = 6-10 in each group), administered using mini-osmotic pumps. Food intake, body weight, plasma leptin concentrations, plasma insulin and blood glucose were measured at baseline and throughout the study period. Nicotine treatment reduced food intake by up to 40% in lean and obese P. obesus. Plasma leptin levels fell significantly only in lean nicotine-treated animals, whereas no changes were observed in obese nicotine-treated animals. However, both lean and obese nicotine-treated animals had similar reductions in body weight. Our results show that nicotine has dramatic effects on food intake and body weight, however, these changes appear to be independent of the leptin signalling pathway.
Notes The definitive version is available at www.blackwell-synergy.com
Language eng
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2002, Blackwell Science Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001710

Document type: Journal Article
Collections: School of Health Sciences
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Created: Mon, 07 Jul 2008, 08:04:34 EST