Exercise and skeletal muscle gene expression

Cameron-Smith, David 2002, Exercise and skeletal muscle gene expression, Clinical and experimental pharmacology and physiology, vol. 29, no. 3, pp. 209-213.

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Title Exercise and skeletal muscle gene expression
Author(s) Cameron-Smith, David
Journal name Clinical and experimental pharmacology and physiology
Volume number 29
Issue number 3
Start page 209
End page 213
Publisher Blackwell Publishing Asia Pty Ltd
Place of publication Carlton, Vic.
Publication date 2002
ISSN 0305-1870
1440-1681
Keyword(s) mRNA
myofibre
satellite cells
training
transcription
Summary 1. Skeletal muscle is a complex and heterogenous tissue capable of remarkable adaptation in response to exercise training. The role of gene transcription, as an initial target to control protein synthesis, is poorly understood.
2. Mature myofibres contain several hundred nuclei, all of which maintain transcriptional competency, although the localized responsiveness of nuclei is not well known. Myofibres are capable of hypertrophy. These processes require the activation and myogenic differentiation of mononuclear satellite cells that fuse with the enlarging or repairing myofibre.
3. A single bout of exercise in human subjects is capable of activating the expression of many diverse groups of genes.
4. The impact of repeated exercise bouts, typical of exercise training, on gene expression has yet to receive systematic investigation.
5. The molecular programme elicited by resistance exercise and endurance exercise differs markedly. Muscular hypertrophy following resistance exercise is dependent on the activation of satellite cells and their subsequent myogenic maturation. Endurance exercise requires the simultaneous activation of mitochondrial and nuclear genes to enable mitochondrial biogenesis.
6. Future analysis of the regulation of genes by exercise may combine high-throughput technologies, such as gene-chips, enabling the rapid detection and analysis of changes in the expression of many thousands of genes.
Language eng
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001712

Document type: Journal Article
Collection: School of Health Sciences
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