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The zebrafish as a model system for human disease

Ward, Alister and Lieschke, Graham J. 2002, The zebrafish as a model system for human disease, Frontiers in bioscience, vol. 7, no. 1-3, pp. d827-d833, doi: 10.2741/ward.

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Title The zebrafish as a model system for human disease
Author(s) Ward, AlisterORCID iD for Ward, Alister
Lieschke, Graham J.
Journal name Frontiers in bioscience
Volume number 7
Issue number 1-3
Start page d827
End page d833
Publisher Frontiers in Bioscience
Place of publication Tampa, Fla.
Publication date 2002-04-01
ISSN 1093-9946
Summary The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. This review aims to describe several representative examples of how the zebrafish can be successfully used to identify novel genes and assign gene function, providing invaluable clues to human pathophysiology.
Notes Table of contents 1. Abstract 2. Introduction 3. Disease models 3.1. Hematopoietic models 3.2. Renal models 3.3. Cardiac models 3.4. Other developmental diseases 4. Perspective 5. Acknowledgements 6. References
Language eng
DOI 10.2741/ward
Field of Research 110311 Medical Genetics (excl Cancer Genetics)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Frontiers in Bioscience
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Document type: Journal Article
Collection: School of Medicine
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