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The effect of water deprivation on the expression of atrial natriuretic pepide and its receptors in the spinifex hopping mouse, Notomys alexis

Heimeier, Rachel, Davis, Belinda and Donald, John 2002, The effect of water deprivation on the expression of atrial natriuretic pepide and its receptors in the spinifex hopping mouse, Notomys alexis, Comparative biochemistry and physiology - part A molecular & integrative physiology, vol. 132, no. 4, pp. 893-903, doi: 10.1016/S1095-6433(02)00116-2.

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Title The effect of water deprivation on the expression of atrial natriuretic pepide and its receptors in the spinifex hopping mouse, Notomys alexis
Author(s) Heimeier, Rachel
Davis, Belinda
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Journal name Comparative biochemistry and physiology - part A molecular & integrative physiology
Volume number 132
Issue number 4
Start page 893
End page 903
Publisher Elsevier Science Inc.
Place of publication New York, N.Y.
Publication date 2002-08
ISSN 1095-6433
1531-4332
Keyword(s) Atrial natriuretic peptide (ANP)
Natriuretic peptide receptor (NPR)
mRNA expression
Water deprivation
Water balance
Spinifex hopping mouse
Heart
Kidney
Summary This study investigated the mRNA expression of the atrial natriuretic peptide (ANP) system (peptide and receptors) during water deprivation in the spinifex hopping mouse, Notomys alexis, a native of central and western Australia that is well adapted to survive in arid environments. Initially, ANP, NPR-A and NPR-C cDNAs (partial for receptors) were cloned and sequenced, and were shown to have high homology with those of rat and mouse. Using a semi-quantitative multiplex PCR technique, the expression of cardiac ANP mRNA and renal ANP, NPR-A, and NPR-C mRNA was determined in 7- and 14-day water-deprived hopping mice, in parallel with control mice (access to water). The levels of ANP mRNA expression in the heart remained unchanged, but in the kidney ANP mRNA levels were increased in the 7-day water-deprived mice, and were significantly decreased in the 14-day water-deprived mice. NPR-A mRNA levels were significantly higher in 7-day water-deprived mice while no change for NPR-A mRNA expression was observed in 14-day water-deprived mice. No variation in NPR-C mRNA levels was observed. This study shows that water deprivation differentially affects the expression of the ANP system, and that renal ANP expression is more important than cardiac ANP in the physiological adjustment to water deprivation.
Language eng
DOI 10.1016/S1095-6433(02)00116-2
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, Elsevier Science Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001779

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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