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Toad atrial natriuretic peptide : cDNA cloning and functional analysis in isolated perfused kidneys

Donald, John, Meier, Stuart and Riddell, Shane 2002, Toad atrial natriuretic peptide : cDNA cloning and functional analysis in isolated perfused kidneys, Physiological and biochemical zoology, vol. 75, no. 6, pp. 617-626, doi: 10.1086/344740.

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Title Toad atrial natriuretic peptide : cDNA cloning and functional analysis in isolated perfused kidneys
Author(s) Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Meier, Stuart
Riddell, Shane
Journal name Physiological and biochemical zoology
Volume number 75
Issue number 6
Start page 617
End page 626
Publisher University of Chicago Press
Place of publication Chicago, Ill.
Publication date 2002
ISSN 1522-2152
1537-5293
Summary Complementary DNA (cDNA) encoding Bufo marinus (toad) preproatrial natriuretic peptide (preproANP) was isolated by reverse-transcription polymerase chain reaction. Sequence analysis of toad preproANP cDNA revealed an open reading frame of 150 amino acid residues, which shared 72% and 66% identity with Rana catesbeiana and Xenopus laevis preproANP, respectively. The deduced amino acid sequence of toad ANP that corresponded to ANP 1–24 of R. catesbeiana and Rana ridibunda was identical, but it differed by four residues from that of X. laevis. ANP mRNA transcripts were also shown to be expressed in the toad kidney. Subsequently, the effect of frog ANP (1–24) on renal function in toad was examined using a perfused kidney preparation. The arterial infusion of frog ANP caused a dose-dependent decrease in the arterial perfusion pressure that was associated with an increase in the glomerular filtration rate (GFR) and a renal natriuresis and diuresis. The renal natriuresis and diuresis resulted predominantly from an increased GFR rather than from direct tubular effects. This study demonstrates that ANP can regulate renal function, which suggests it may be involved in overall fluid volume regulation.
Language eng
DOI 10.1086/344740
Field of Research 060603 Animal Physiology - Systems
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2002, The University of Chicago.
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001856

Document type: Journal Article
Collections: School of Biological and Chemical Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.