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Regulation of glucose kinetics during intense exercise in humans: effects of α- and β-adrenergic blockade

Howlett, Kirsten, Watt, Matthew J., Hargreaves, Mark and Febbraio, Mark A. 2003, Regulation of glucose kinetics during intense exercise in humans: effects of α- and β-adrenergic blockade, Metabolism, clinical and experimental, vol. 52, no. 12, pp. 1615-1620.

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Title Regulation of glucose kinetics during intense exercise in humans: effects of α- and β-adrenergic blockade
Author(s) Howlett, Kirsten
Watt, Matthew J.
Hargreaves, Mark
Febbraio, Mark A.
Journal name Metabolism, clinical and experimental
Volume number 52
Issue number 12
Start page 1615
End page 1620
Publisher W B Saunders Co
Place of publication Philadelphia, Pa.
Publication date 2003-12
ISSN 0026-0495
Summary This study examined the effect of combined α- and β-adrenergic blockade on glucose kinetics during intense exercise. Six endurance-trained men exercised for 20 minutes at approximately 78% of their peak oxygen consumption (VO 2) following ingestion of a placebo (CON) or combined α- (prazosin hydrochloride) and β- (timolol maleate) adrenoceptor antagonists (BLK). Plasma glucose increased during exercise in CON (0 minutes: 5.5 ± 0.1; 20 minutes: 6.5 ± 0.3 mmol · L−1, P < .05). In BLK, the exercise-induced increase in plasma glucose was abolished (0 minutes: 5.7 ± 0.3; 20 minutes: 5.7 ± 0.1 mmol · L−1). Glucose kinetics were measured using a primed, continuous infusion of [6,6-2H] glucose. Glucose production was not different between trials; on average these values were 25.3 ± 3.9 and 30.9 ± 4.4 μmol · kg−1 · min−1 in CON and BLK, respectively. Glucose uptake during exercise was greater (P < .05) in BLK (30.6 ± 4.6 μmol · kg−1 · min−1) compared with CON (18.4 ± 2.5 μmol · kg−1 · min−1). In BLK, plasma insulin and catecholamines were higher (P < .05), while plasma glucagon was unchanged from CON. Free fatty acids (FFA) and glycerol were lower (P < .05) in BLK. These findings demonstrate that adrenergic blockade during intense exercise results in a blunted plasma glucose response that is due to enhanced glucose uptake, with no significant change in glucose production.
Notes Available online 27 November 2003.
Language eng
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30001890

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