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Guanylyl cyclase stimulation by homologous and heterologous natriuretic peptides in salmonids

Callahan, Will, McWilliam, Hamish, Powell, Mark D. and Toop, Tes 2002, Guanylyl cyclase stimulation by homologous and heterologous natriuretic peptides in salmonids, Fish physiology and biochemistry, vol. 26, no. 2, pp. 129-138.

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Title Guanylyl cyclase stimulation by homologous and heterologous natriuretic peptides in salmonids
Author(s) Callahan, Will
McWilliam, Hamish
Powell, Mark D.
Toop, Tes
Journal name Fish physiology and biochemistry
Volume number 26
Issue number 2
Start page 129
End page 138
Publisher Kluwer Academic Publishers
Place of publication Amsterdam, Netherlands
Publication date 2002
ISSN 0920-1742
1573-5168
Keyword(s) ANP
Atlantic salmon
CNP
gill
kidney
rainbow trout
receptor
salinity
teleost
VNP
Summary A range of homologous (trout ANP, trout CNP, trout VNP) and heterologous (eel ANP, eel ANP-NH2, rat ANP, porcine CNP) NPs were tested for their effect on guanylyl cyclase in gill and kidney membrane preparations from freshwater and seawater-acclimated rainbow trout and Atlantic salmon. All NPs stimulated guanylyl cyclase at 1 µmol l-1in all preparations. ANP was the most potent stimulator of kidney guanylyl cyclase and CNP the most potent stimulator of guanylyl cyclase in gills. Some differences were apparent between the potencies of homologous and heterologous peptides at 1 µmol l-1: tANP was more potent than rANP in the SW trout kidney and tCNP was more potent than pCNP in FW salmon tissues. While eANP was more potent than tANP in trout gills, it was less potent than tANP in FW salmon gills. However, there was no significant difference between the potencies of eANP and eANP-NH2 in trout or salmon gills. Salinity did not affect guanylyl cyclase activity with the exception that trout ANP at 1 µmol l-1was more potent in SW trout kidneys than in FW trout kidneys. These results suggest a predomination of NPR-A in the kidney and NPR-B in the gill. It appears that salmonid NPR-A and NPR-B are relatively promiscuous in their ligand affinity, with few differences in the potencies of trout and mammalian NPs and only small differences in cGMP production where these differences do occur.
Language eng
Field of Research 060602 Animal Physiology - Cell
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2003
Copyright notice ©2003, Kluwer Academic Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002051

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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