Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men

Newman, Jackie, Hargreaves, Mark, Garnham, Andrew and Snow, Rodney 2003, Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men, Medicine and science in sports and exercise, vol. 35, no. 1, pp. 69-74.


Title Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men
Author(s) Newman, Jackie
Hargreaves, Mark
Garnham, Andrew
Snow, Rodney
Journal name Medicine and science in sports and exercise
Volume number 35
Issue number 1
Start page 69
End page 74
Publisher American College of Sports Medicine
Place of publication Madison, Wis.
Publication date 2003-01
ISSN 0195-9131
1530-0315
Keyword(s) ergogenic aid
glycogen
insulin action
Summary Purpose: This study investigated whether acute (5 d) and/or short-term (28 d) creatine (Cr) ingestion altered glucose tolerance or insulin action in healthy, untrained men (aged 26.9 ± 5.7 yr; SD). Methods : Subjects were randomly allocated to either a Cr (N = 8) or placebo group (N = 9) and were tested in the control condition (presupplementation), and after 5 and a further 28 d of supplementation. The Cr group ingested 20 g and 3 g·d-1 of Cr for the first 5 and following 28 d, respectively. The placebo group ingested similar amounts of glucose over the same time period. During each testing period, subjects underwent an oral glucose tolerance test (OGTT) to determine insulin sensitivity, and six subjects from each group underwent a muscle biopsy before each OGTT. Results : Cr supplementation resulted in an increased (P < 0.05) muscle TCr content after both the acute and short-term loading phase compared with placebo. Neither acute nor short-term Cr supplementation influenced skeletal muscle glycogen content, glucose tolerance, or measures of insulin sensitivity. Conclusions: These findings demonstrated that acute Cr supplementation (20 g·d-1 for 5 d) followed by short-term Cr supplementation (3 g·d-1 for 28 d) did not alter insulin action in healthy, active untrained men.
Language eng
Field of Research 111601 Cell Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, American College of Sports Medicine
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002088

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