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The taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity

Southon, A., Walder, K., Sanigorski, A. M., Zimmet, P., Nicholson, G. C., Kotowicz, M. and Collier, G. 2003, The taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity, Diabetes, nutrition & metabolism, vol. 16, no. 1, pp. 72-76.

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Title The taq IA and Ser311Cys polymorphisms in the dopamine D2 receptor gene and obesity
Author(s) Southon, A.
Walder, K.
Sanigorski, A. M.
Zimmet, P.
Nicholson, G. C.
Kotowicz, M.
Collier, G.
Journal name Diabetes, nutrition & metabolism
Volume number 16
Issue number 1
Start page 72
End page 76
Publisher Editrice Kurtis
Place of publication Milano, Italy
Publication date 2003
ISSN 0394-3402
Keyword(s) dopamine D2 receptor
obesity
association
polymorphism
Summary Dopamine D2 receptors (DRD2) in the central nervous system are involved in the regulation of feeding. It remains to be elucidated if mutations in the DRD2 gene contribute to the development of obesity. The aim of the present study was to investigate whether the Taq IA and Ser311Cys polymorphisms in the DRD2 gene are associated with obesity in Nauruan and Australian subjects. Subjects were selected based on extremes of the body mass index (BMI) distribution. Two groups of Australian women were selected. The leanest group had a mean BMI of 22.5 kg/m2 (range: 20.3-24.3) and the heaviest group had a mean of 36.1 kg/m2 (32.5-44.1). Four groups of Nauruan subjects were selected. Leanest men had a mean BMI of 33.0 kg/m2 (28.4-36.9), heaviest men had a mean of 52.8 kg/m2 (46.5-69.2), leanest women had a mean of 34.8 kg/m2 (28.2-41.8) and heaviest women had a mean of 55.1 kg/m2 (49.3-73.8). Subjects were genotyped for the Taq IA and Ser311Cys polymorphisms using polymerase chain reaction (PCR) restriction fragment length polymorphism analysis and allelic discrimination TaqmanTM PCR respectively. Leanest and heaviest groups were examined for differences in genotype frequency. Taq IA and Ser311Cys genotype frequencies did not differ significantly between leanest and heaviest Nauruan groups, or between leanest and heaviest Australians. Haplotype frequencies of these polymorphisms did not differ between leanest and heaviest groups. The Taq IA and Ser311Cys polymorphisms in the DRD2 gene are unlikely to be common causes of obesity in these populations.
Language eng
Field of Research 060499 Genetics not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, Editrice Kurtis.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002124

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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