Decreasing dietary sodium while following a self-selected potassium-rich diet reduces blood pressure

Nowson, Caryl, Morgan, Trefor O. and Gibbons, Carl 2003, Decreasing dietary sodium while following a self-selected potassium-rich diet reduces blood pressure, Journal of nutrition, vol. 133, no. 12, pp. 4118-4123.

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Title Decreasing dietary sodium while following a self-selected potassium-rich diet reduces blood pressure
Author(s) Nowson, CarylORCID iD for Nowson, Caryl
Morgan, Trefor O.
Gibbons, Carl
Journal name Journal of nutrition
Volume number 133
Issue number 12
Start page 4118
End page 4123
Publisher American Society for Clinical Nutrition
Place of publication Bethesda, MD
Publication date 2003-12
ISSN 0022-3166
Keyword(s) home blood pressure
Summary Reducing dietary sodium reduces blood pressure (BP), a major risk factor for cardiovascular disease, but few studies have specifically examined the effect on BP of altering dietary sodium in the context of a high potassium diet. This randomized, crossover study compared BP values in volunteer subjects self-selecting food intake and consuming low levels of sodium (Na+; 50 mmol/d) with those consuming high levels of sodium (> or =20 mmol/d), in the context of a diet rich in potassium (K+). Sodium supplementation (NaSp) produced the difference in Na+ intake. Subjects (n = 108; 64 women, 44 men; 16 on antihypertensive therapy) had a mean age of 47.0 ± 10.1 y. Subjects were given dietary advice to achieve a low sodium (LS) diet with high potassium intake (50 mmol Na+/d, >80 mmol K+/d) and were allocated to NaSp (120 mmol Na+/d) or placebo treatment for 4 wk before crossover. The LS diet decreased urinary Na+ from baseline, 138.7 ± 5.3 mmol/d to 57.8 ± 3.8 mmol/d (P < 0.001). The NaSp treatment returned urinary Na+ to baseline levels 142.4 ± 3.7 mmol/d. Urinary K+ increased from baseline, 78.6 ± 2.3 to 86.6 ± 2.1 mmol/d with the LS diet and to 87.1 ± 2.1 mmol/d with NaSp treatment (P < 0.001). The LS diet reduced home systolic blood pressure (SBP) by 2.5 ± 0.8 mm Hg (P = 0.004), compared with the NaSp treatment. Hence, reducing Na+ intake from 140 to 60 mmol/d significantly decreased home SBP in subjects dwelling in a community setting who consumed a self-selected K+-rich diet, and this dietary modification could assist in lowering blood pressure in the general population.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, American Society for Nutritional Sciences
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