Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice

Snow, Rod, Turnbull, J., Da Silva, S., Jiang, F. and Tarnopolsky, M. A. 2003, Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice, Neuroscience, vol. 119, no. 3, pp. 661-667.

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Title Creatine supplementation and riluzole treatment provide similar beneficial effects in copper, zinc superoxide dismutase (G93A) transgenic mice
Author(s) Snow, Rod
Turnbull, J.
Da Silva, S.
Jiang, F.
Tarnopolsky, M. A.
Journal name Neuroscience
Volume number 119
Issue number 3
Start page 661
End page 667
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2003-07-04
ISSN 0306-4522
1873-7544
Keyword(s) motor neuron disease
amyotrophic lateral sclerosis
superoxide dismutase
nutritional supplement
Summary This study investigated the effects of riluzole (Ril), creatine (Cr) and a combination of these treatments on the onset and progression of clinical signs and neuropathology in an animal model of familial amyotrophic lateral sclerosis, the G93A transgenic mouse (n=13–17 per group). The onset of clinical signs was delayed (P<0.05) by about 12 days in all treatment groups compared with control; however, no differences occurred between treatments. All animals were killed at 199 days of age. At the end of the experimental period the severity of clinical signs was less (P<0.05) with all treatments compared with control. Again no differences between treatments were observed. The treatments had no effect on the number of neurons in ventral horns of the lumbar region of the spinal cord. Transgenic mice ingesting Cr displayed elevated (P<0.05) total Cr levels in cerebral hemispheres (5%) and spinal cord (8%), but not skeletal muscles. These data demonstrate that treatment with Ril and Cr were both effective in delaying disease onset and clinical disability. To the age of killing, no additional benefit was conferred by co-administration of Ril and Cr.
Notes Available online 23 May 2003.
Language eng
Field of Research 060604 Comparative Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2003, IBRO
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002303

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