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Skeletal muscle total creatine content and creatine transporter gene expression in vegetarians prior to and following creatine supplementation

Watt, Kenneth, Garnham, Andrew and Snow, Rodney 2004, Skeletal muscle total creatine content and creatine transporter gene expression in vegetarians prior to and following creatine supplementation, International Journal of sport nutrition and exercise metabolism, vol. 14, no. 5, pp. 517-531.

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Title Skeletal muscle total creatine content and creatine transporter gene expression in vegetarians prior to and following creatine supplementation
Author(s) Watt, Kenneth
Garnham, Andrew
Snow, Rodney
Journal name International Journal of sport nutrition and exercise metabolism
Volume number 14
Issue number 5
Start page 517
End page 531
Publisher Human Kinetics Publishers
Place of publication Champaign, Ill.
Publication date 2004-10
ISSN 1526-484X
Keyword(s) Creatine transporter
Ergogenic aid
Gene expression
Nutritional supplement
Summary This study examined the effect of vegetarianism on skeletal muscle total creatine (TCr) content and creatine transporter (CreaT) gene expression, prior to and during 5 d of Cr supplementation (CrS). In a double-blind, crossover design, 7 vegetarians (VEG) and nonvegetarians (NVEG) were assigned Cr or placebo supplements for 5 d and after 5 wk, received the alternative treatment. Muscle sampling occurred before, and after 1 and 5 d of treatment ingestion. Basal muscle TCr content was lower (P < 0.05) in VEG compared with NVEG. Muscle TCr increased (P < 0.05) throughout the Cr trial in both groups but was greater (P < 0.05) in VEG compared with NVEG, at days 1 and 5. CreaT gene expression was not different between VEG and NVEG. The results indicate that VEG have a lower muscle TCr content and an increased capacity to load Cr into muscle following CrS. Muscle CreaT gene expression does not appear to be affected by vegetarianism.
Language eng
Field of Research 111601 Cell Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, Human Kinetics Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002430

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Created: Mon, 07 Jul 2008, 08:24:30 EST