Muscle glycogen and metabolic regulation

Hargreaves, Mark 2004, Muscle glycogen and metabolic regulation, The proceedings of the nutrition society, vol. 63, no. 2, pp. 217-220, doi: 10.1079/PNS2004344.

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Title Muscle glycogen and metabolic regulation
Author(s) Hargreaves, Mark
Journal name The proceedings of the nutrition society
Volume number 63
Issue number 2
Start page 217
End page 220
Publisher Cambridge University Press
Place of publication Cambridge, England
Publication date 2004-05
ISSN 0029-6651
Keyword(s) glycogen
skeletal muscle
Summary Muscle glycogen is an important fuel for contracting skeletal muscle during prolonged strenuous exercise, and glycogen depletion has been implicated in muscle fatigue. It is also apparent that glycogen availability can exert important effects on a range of metabolic and cellular processes. These processes include carbohydrate, fat and protein metabolism during exercise, post-exercise glycogen resynthesis, excitation–contraction coupling, insulin action and gene transcription. For example, low muscle glycogen is associated with reduced muscle glycogenolysis, increased glucose and NEFA uptake and protein degradation, accelerated glycogen resynthesis, impaired excitation–contraction coupling, enhanced insulin action and potentiation of the exercise-induced increases in transcription of metabolic genes. Future studies should identify the mechanisms underlying, and the functional importance of, the association between glycogen availability and these processes.
Language eng
DOI 10.1079/PNS2004344
Field of Research 060104 Cell Metabolism
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, The Author
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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