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Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein

Gao, Yuan, Feng, Helen C., Walder, Ken, Bolton, Kristy, Sunderland, Terry, Bishara, Natalie, Quick, Melissa, Kantham, Lakshmi and Collier, Greg R. 2004, Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein, FEBS letters, vol. 563, no. 1-3, pp. 185-190.

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Title Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein
Author(s) Gao, Yuan
Feng, Helen C.
Walder, Ken
Bolton, Kristy
Sunderland, Terry
Bishara, Natalie
Quick, Melissa
Kantham, Lakshmi
Collier, Greg R.
Journal name FEBS letters
Volume number 563
Issue number 1-3
Start page 185
End page 190
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2004-04-09
ISSN 0014-5793
Keyword(s) selenoprotein
glucose-regulated protein
glucose deprivation
endoplasmic reticulum stress
gene expression
Summary SelS is a newly identified selenoprotein and its gene expression is up-regulated in the liver of Psammomys obesus after fasting. We have examined whether SelS is regulated by glucose deprivation and endoplasmic reticulum (ER) stress in HepG2 cells. Glucose deprivation and the ER stress inducers tunicamycin and thapsigargin increased SelS gene expression and protein content several-fold in parallel with glucose-regulated protein 78. The overexpression of SelS increased Min6 cell resistance to oxidative stress-induced toxicity. These results indicate that SelS is a novel member of the glucose-regulated protein family and its function is related to the regulation of cellular redox balance.
Notes Available online 19 March 2004.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002457

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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