Harnessing zebrafish for the study of white blood cell development and its perturbation

Onnebo, Sara M.N., Yoong, Simon H.S. and Ward, Alister 2004, Harnessing zebrafish for the study of white blood cell development and its perturbation, Experimental hematology, vol. 32, no. 9, pp. 789-796.

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Title Harnessing zebrafish for the study of white blood cell development and its perturbation
Author(s) Onnebo, Sara M.N.
Yoong, Simon H.S.
Ward, Alister
Journal name Experimental hematology
Volume number 32
Issue number 9
Start page 789
End page 796
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2004-09
ISSN 0301-472X
1873-2399
Keyword(s) zebrafish
hematopoiesis
Summary Considerable progress has been made in understanding the molecular basis of normal white blood cell development and its perturbation in disease through the use of clinical studies and traditional animal and cell line models. Despite this, however, many questions are still being answered and white blood cell disorders, including leukemia and lymphoma, remain a significant health problem. The zebrafish (Danio rerio) has emerged as a powerful alternative vertebrate model for the study of development and disease. We review the recent application of zebrafish to the study of white blood cell development and its disruption, particularly leukemogenesis. Such studies have highlighted the overall conservation of these processes throughout vertebrates, and establish zebrafish as a useful experimental model. This organism is now poised to make an important contribution to our understanding of the underlying genetic control of white blood cell development and its disruption, as well as the identification of new therapeutic agents.
Language eng
Field of Research 110202 Haematology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, International Society for Experimental Hematology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002474

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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