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Diverse eukaryotes have retained mitochondrial homologues of the bacterial division protein FtsZ

Kiefel, Ben, Gilson, Paul and Beech, Peter 2004, Diverse eukaryotes have retained mitochondrial homologues of the bacterial division protein FtsZ, Protist, vol. 155, no. 1, pp. 105-115, doi: 10.1078/1434461000168.

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Title Diverse eukaryotes have retained mitochondrial homologues of the bacterial division protein FtsZ
Author(s) Kiefel, Ben
Gilson, Paul
Beech, Peter
Journal name Protist
Volume number 155
Issue number 1
Start page 105
End page 115
Publisher Elsevier B.V.
Place of publication Amsterdam, The Netherlands
Publication date 2004-03
ISSN 1434-4610
Keyword(s) Mitochondrion
chloroplast
organelle
division
FtsZ
evolution
Summary Mitochondrial fission requires the division of both the inner and outer mitochondrial membranes. Dynamin-related proteins operate in division of the outer membrane of probably all mitochondria, and also that of chloroplasts – organelles that have a bacterial origin like mitochondria. How the inner mitochondrial membrane divides is less well established. Homologues of the major bacterial division protein, FtsZ, are known to reside inside mitochondria of the chromophyte alga Mallomonas, a red alga, and the slime mould Dictyostelium discoideum, where these proteins are likely to act in division of the organelle. Mitochondrial FtsZ is, however, absent from the genomes of higher eukaryotes (animals, fungi, and plants), even though FtsZs are known to be essential for the division of probably all chloroplasts. To begin to understand why higher eukaryotes have lost mitochondrial FtsZ, we have sampled various diverse protists to determine which groups have retained the gene. Database searches and degenerate PCR uncovered genes for likely mitochondrial FtsZs from the glaucocystophyte Cyanophora paradoxa, the oomycete Phytophthora infestans, two haptophyte algae, and two diatoms – one being Thalassiosira pseudonana, the draft genome of which is now available. From Thalassiosira we also identified two chloroplast FtsZs, one of which appears to be undergoing a C-terminal shortening that may be common to many organellar FtsZs. Our data indicate that many protists still employ the FtsZ-based ancestral mitochondrial division mechanism, and that mitochondrial FtsZ has been lost numerous times in the evolution of eukaryotes.
Language eng
DOI 10.1078/1434461000168
Field of Research 060409 Molecular Evolution
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002476

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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