The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis

Heimeier, Rachel, Bartolo, Rav and Donald, John 2004, The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis, Australian mammalogy, vol. 26, no. 2, pp. 191-198.

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Title The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis
Author(s) Heimeier, Rachel
Bartolo, Rav
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Journal name Australian mammalogy
Volume number 26
Issue number 2
Start page 191
End page 198
Publisher Australian Mammal Society
Place of publication Adelaide, S. Aust.
Publication date 2004-11
ISSN 0310-0049
1836-7402
Keyword(s) cGMP
Natriuretic peptides
Guanylin peptides
Notomys alexis
Kidney
Colon
Summary In mammals the natriuretic and guanylin peptides influence renal and intestinal fluid content and electrolyte transport by binding to and activating guanylyl cyclase (GC) receptors that in turn stimulate production of the intracellular second messenger guanosine 3':5'-cyclic monophospate
(cGMP). However, the role of natriuretic and guanylin peptides in desert mammals is not understood. The spinifex hopping-mouse (Notomys alexis), has a suite of behavioural and physiological mechanisms that permits survival for extended periods without access to free water. Because signalling molecules that generate cGMP are known to promote water excretion, it was predicted that natriuretic and guanylin peptide synthesis would be down regulated in water-deprived N. alexis, and thus reduce the amount of water lost in the urine and faeces. However, in the kidney ANP and GC-A mRNA levels were increased in water-deprived mice, but CNP and GC-B mRNA levels were decreased. Water deprivation increased guanylin and uroguanylin mRNA expression in the distal colon, but it remained unchanged in the kidney and proximal colon. The expression of GC-C mRNA increased in the proximal colon but not in the distal colon. This study shows that water deprivation differentially affects the expression of regulatory molecules that stimulate cGMP producti
Language eng
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, Australian Mammal Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002715

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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