The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis Heimeier, Rachel, Bartolo, Rav and Donald, John 2004, The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis, Australian mammalogy, vol. 26, no. 2, pp. 191-198. Attached Files Name Description MIMEType Size Downloads Title The effect of water deprivation on signalling molecules that utilise cGMP in the Spinifex Hopping Mouse Notomys alexis Author(s) Heimeier, Rachel Bartolo, Rav Donald, John orcid.org/0000-0001-5930-2642 Journal name Australian mammalogy Volume number 26 Issue number 2 Start page 191 End page 198 Publisher Australian Mammal Society Place of publication Adelaide, S. Aust. Publication date 2004-11 ISSN 0310-0049 1836-7402 Keyword(s) cGMP Natriuretic peptides Guanylin peptides Notomys alexis Kidney Colon Summary In mammals the natriuretic and guanylin peptides influence renal and intestinal fluid content and electrolyte transport by binding to and activating guanylyl cyclase (GC) receptors that in turn stimulate production of the intracellular second messenger guanosine 3':5'-cyclic monophospate (cGMP). However, the role of natriuretic and guanylin peptides in desert mammals is not understood. The spinifex hopping-mouse (Notomys alexis), has a suite of behavioural and physiological mechanisms that permits survival for extended periods without access to free water. Because signalling molecules that generate cGMP are known to promote water excretion, it was predicted that natriuretic and guanylin peptide synthesis would be down regulated in water-deprived N. alexis, and thus reduce the amount of water lost in the urine and faeces. However, in the kidney ANP and GC-A mRNA levels were increased in water-deprived mice, but CNP and GC-B mRNA levels were decreased. Water deprivation increased guanylin and uroguanylin mRNA expression in the distal colon, but it remained unchanged in the kidney and proximal colon. The expression of GC-C mRNA increased in the proximal colon but not in the distal colon. This study shows that water deprivation differentially affects the expression of regulatory molecules that stimulate cGMP producti Language eng Field of Research 060603 Animal Physiology - Systems HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2004, Australian Mammal Society Persistent URL http://hdl.handle.net/10536/DRO/DU:30002715 Document type: Journal Article Collection: School of Biological and Chemical Sciences   Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 12 Jan 2009, 08:54:33 EST Wed, 15 Jul 2009, 10:13:30 EST Fri, 28 Aug 2009, 11:11:48 EST Fri, 13 Jun 2014, 22:41:14 EST Mon, 19 Jan 2015, 10:11:53 EST Sat, 13 Jan 2018, 01:41:38 EST Tue, 23 Jan 2018, 09:35:12 EST Tue, 23 Jan 2018, 11:03:25 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 1 times in Scopus Search Google Scholar Access Statistics: 610 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 07 Jul 2008, 08:32:29 EST

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