Preliminary evaluation of dual acidic potassium permanganate and tris(2,2`-bipyridyl)ruthenium(II) chemiluminescence detection for the HPLC determination of Papaver somniferum alkaloids

Lenehan, Claire, Barnett, Neil, Lewis, Simon and Essery, Kevin 2004, Preliminary evaluation of dual acidic potassium permanganate and tris(2,2`-bipyridyl)ruthenium(II) chemiluminescence detection for the HPLC determination of Papaver somniferum alkaloids, Australian journal of chemistry, vol. 57, no. 10, pp. 1001-1004.

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Title Preliminary evaluation of dual acidic potassium permanganate and tris(2,2`-bipyridyl)ruthenium(II) chemiluminescence detection for the HPLC determination of Papaver somniferum alkaloids
Author(s) Lenehan, Claire
Barnett, Neil
Lewis, Simon
Essery, Kevin
Journal name Australian journal of chemistry
Volume number 57
Issue number 10
Start page 1001
End page 1004
Publisher CSIRO Publishing
Place of publication Collingwood, Vic.
Publication date 2004-10-01
ISSN 0004-9425
1445-0038
Summary This paper describes a dual chemiluminescence reagent for the determination of the opiate alkaloids morphine, codeine, oripavine, and thebaine in Papaver somniferum extracts. Detection was achieved using a mixture of acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(ii), where the former acted as both the oxidant for the latter and as a chemiluminescence reagent in its own right. The analytes were separated on a C8 column using ion-pairing HPLC. The application of the mixed reagent detection compared favourably with results obtained using standard HPLC methodology. Detection limits for the alkaloids were 10-6, 5 × 10-7, 3 × 10-6, and 2 × 10-6 mol L-1 for morphine, codeine, oripavine, and thebaine, respectively.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2004, CSIRO Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30002785

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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