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Spatio-temporal selectivity of loss of colour and luminance contrast sensitivity with mutiple sclerosis and optic neuritis

Flanagan, Patrick and Markulev, Connie 2005, Spatio-temporal selectivity of loss of colour and luminance contrast sensitivity with mutiple sclerosis and optic neuritis, Ophthalmic and Physiological Optics, vol. 25, no. 1, pp. 57-65, doi: 10.1111/j.1475-1313.2004.00252.x.

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Title Spatio-temporal selectivity of loss of colour and luminance contrast sensitivity with mutiple sclerosis and optic neuritis
Author(s) Flanagan, Patrick
Markulev, Connie
Journal name Ophthalmic and Physiological Optics
Volume number 25
Issue number 1
Start page 57
End page 65
Publisher Pergamon Press
Place of publication Oxford, England
Publication date 2005-01
ISSN 0275-5408
1475-1313
Keyword(s) Colour vision
Luminance vision
Multiple sclerosis
Optic neuritis
Summary Colour and luminance-contrast thresholds were measured in the presence of dynamic Random Luminance-contrast Masking (RLM) in individuals who had had past diagnoses of optic neuritis (ON) some of whom have progressed to a diagnosis of multiple sclerosis (MS). To explore the spatio-temporal selectivity of chromatic and luminance losses in MS/ON, thresholds were measured using three different sizes and modulation rates of the RLM displays: small checks modulating slowly, medium-sized checks with moderate modulation and large checks modulating rapidly. The colour of the chromatic stimuli used were specified in a cone-excitation space to measure relative impairments in red–green and blue–yellow chromatic channels. These observers showed chromatic thresholds along the L/(L + M) axis that were higher than those along the S-cone axis for all display sizes/modulation rates and both red-green and blue-yellow colour thresholds were higher than luminance-contrast thresholds. The principal change in thresholds with spatio-temporal changes in the display was a reduction in thresholds for L/(L + M) and S-cones with increasing check size and modulation rate. However, luminance contrast thresholds did not change with display size/rate. These results are consistent with MS/ON selectively affecting processing in colour pathways rather than in the magnocellular pathway, and that within the colour pathways neurones with opposed L- and M-cone inputs are more damaged than colour-opponent neurons with input from S-cones.
Language eng
DOI 10.1111/j.1475-1313.2004.00252.x
Field of Research 170101 Biological Psychology (Neuropsychology, Psychopharmacology, Physiological Psychology)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, The College of Optometrists
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003094

Document type: Journal Article
Collection: School of Psychology
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