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Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial

Desneves, Katherine J., Todorovic, Bree E., Cassar, Ann and Crowe, Timothy C. 2005, Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial, Clinical nutrition, vol. 24, no. 6, pp. 979-987.

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Title Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: A randomised controlled trial
Author(s) Desneves, Katherine J.
Todorovic, Bree E.
Cassar, Ann
Crowe, Timothy C.
Journal name Clinical nutrition
Volume number 24
Issue number 6
Start page 979
End page 987
Publisher Churchill Livingstone
Place of publication Edinburgh, Scotland
Publication date 2005-12
ISSN 0261-5614
Keyword(s) pressure ulcers
healing
nutrition
arginine
malnutrition
Summary Background & Aims
Nutrients putatively implicated in pressure ulcer healing were evaluated in a clinical setting.

Methods
Sixteen inpatients with a stage 2, 3 or 4 pressure ulcer randomised to receive daily a standard hospital diet; a standard diet plus two high-protein/energy supplements; or a standard diet plus two high-protein/energy supplements containing additional arginine (9 g), vitamin C (500 mg) and zinc (30 mg). Nutritional status measurements (dietary, anthropometric and biochemical) and pressure ulcer size and severity (by PUSH tool; Pressure Ulcer Scale for Healing; 0=completely healed, 17=greatest severity) were measured weekly for 3 weeks.

Results
Patients’ age and BMI ranges were 37–92 years and 16.4–28.1 kg/m2, respectively. Baseline PUSH scores were similar between groups (8.7±0.5). Only patients receiving additional arginine, vitamin C and zinc demonstrated a clinically significant improvement in pressure ulcer healing (9.4±1.2 vs. 2.6±0.6; baseline and week 3, respectively; P<0.01). All patient groups presented with low serum albumin and zinc and elevated C-reactive protein. There were no significant changes in biochemical markers, oral dietary intake or weight in any group.

Conclusions
In this small set of patients, supplementary arginine, vitamin C and zinc significantly improved the rate of pressure ulcer healing. The results need to be confirmed in a larger study.
Notes Reproduced with the specific permission of the copyright owner.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003122

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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