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Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves

Donald, John and Broughton, B. 2005, Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, vol. 142, no. 2, pp. 188-197, doi: 10.1016/j.cbpa.2005.07.015.

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Title Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves
Author(s) Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Broughton, B.
Journal name Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Volume number 142
Issue number 2
Start page 188
End page 197
Publisher Elsevier Inc.
Place of publication New York, N.Y.
Publication date 2005-10
ISSN 1095-6433
1531-4332
Keyword(s) nitric oxide
nitric oxide synthase
nitrergic nerves
blood vessel
vasodilation
autonomic nervous system
Summary In mammals, much is understood about the endothelial and neural NO control mechanisms in the vasculature. In contrast, NO control of blood vessels in lower vertebrates is poorly understood, with the majority of research focusing on the presence of an endothelial NO system; however, its presence remains controversial. This study examined the mechanisms by which NO regulates the large blood vessels of non-mammalian vertebrates. In all species examined, the arteries and veins contained a plexus of NOS-positive perivascular nerves that included nerve bundles and fine, varicose nerve terminals. However, in the large arteries and veins of various species of fishes and amphibians, no anatomical evidence was found for endothelial NOS using both NADPH-diaphorase and eNOS immunohistochemistry. In contrast, perinuclear NOS staining was readily apparent in blue-tongue lizard, pigeon and rat, which suggested that eNOS first appeared in reptiles. Physiological analysis of NO signalling in the vascular smooth muscle of short-finned eel and cane toad could not find any evidence for endothelial NO signalling. In contrast, it appears that activation of the nitrergic vasomotor nerves is responsible for NO control of the blood vessels.
Notes Available online 31 August 2005.
Language eng
DOI 10.1016/j.cbpa.2005.07.015
Field of Research 060603 Animal Physiology - Systems
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003179

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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