You are not logged in.

Synergistic antiproliferative action of the Flavonols Quercetin and Kaempferol in cultured human cancer cell lines

Ackland, Leigh, van de Waasenburg, Simone and Jones, Rod 2005, Synergistic antiproliferative action of the Flavonols Quercetin and Kaempferol in cultured human cancer cell lines, In Vivo: international journal of experimental and clinical pathophysiology and drug research, vol. 19, no. 1, pp. 69-76.

Attached Files
Name Description MIMEType Size Downloads

Title Synergistic antiproliferative action of the Flavonols Quercetin and Kaempferol in cultured human cancer cell lines
Author(s) Ackland, LeighORCID iD for Ackland, Leigh orcid.org/0000-0002-7474-6556
van de Waasenburg, Simone
Jones, Rod
Journal name In Vivo: international journal of experimental and clinical pathophysiology and drug research
Volume number 19
Issue number 1
Start page 69
End page 76
Publisher International Institute of Anticancer Research
Place of publication Athens, Greece
Publication date 2005-01
ISSN 0258-851X
Keyword(s) Anticancer effects
Flavonols
Human cells
Summary The consumption of vegetables containing the flavonols quercetin and kaempferol reduces the risk of cancer. We utilized human gut (HuTu-80 and Caco-2) and breast cancer cells (PMC42) to show the synergistic effect of quercetin and kaempferol in reducing cell proliferation. A trend in reduction of total cell counts was seen following a single exposure, a 4-day exposure or a 14-day exposure to quercetin and kaempferol. Combined treatments with quercetin and kaempferol were more effective than the additive effects of each flavonol. The reduction in cell proliferation was associated with decreased expression of nuclear proliferation antigen Ki67 and decreased total protein levels in treated cells relative to controls. In conclusion, the synergistic antiproliferative effect of quercetin and kaempferol demonstrated in cultured human cells has broad implications for understanding the influence of dietary nutrients in vivo, where anticancer effects may be a result of nutrients which act in concert.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 0 Not Applicable
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, International Institute of Anticancer Research
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003181

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 60 times in TR Web of Science
Scopus Citation Count Cited 53 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 975 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Mon, 07 Jul 2008, 08:45:44 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.