Determination of selected neurotransmitter metabolites using monolithic column chromatography coupled with chemiluminescence detection

Adcock, Jacqui L., Barnett, Neil W., Costin, Jason W., Francis, Paul S. and Lewis, Simon W. 2005, Determination of selected neurotransmitter metabolites using monolithic column chromatography coupled with chemiluminescence detection, Talanta, vol. 67, no. 3, pp. 585-589.

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Title Determination of selected neurotransmitter metabolites using monolithic column chromatography coupled with chemiluminescence detection
Author(s) Adcock, Jacqui L.
Barnett, Neil W.
Costin, Jason W.
Francis, Paul S.
Lewis, Simon W.
Journal name Talanta
Volume number 67
Issue number 3
Start page 585
End page 589
Publisher Elsevier BV
Place of publication Amsterdam, Netherlands
Publication date 2005-09-15
ISSN 0039-9140
1873-3573
Keyword(s) neurotransmitter metabolites
monolithic column chromatography;
chemiluminescence detection
Summary The oxidation of selected clinically important neurotransmitter metabolites with acidic potassium permanganate in the presence of polyphosphates evokes chemiluminescence of sufficient intensity to enable the sensitive determination of these species. Limits of detection for 5-hydroxyindole-3-acetic acid (5-HIAA), vanilmandelic acid (VMA; α,4-dihydroxy-3-methoxybenzeneacetic acid), 4-hydroxy-3-methoxyphenylglycol (MHPG), homovanillic acid (HVA, 4-hydroxy-3-methoxyphenylacetic acid) and 3,4-dihydroxyphenylacetic acid (DOPAC) were between 5 × 10−9 and 4 × 10−8 M, using flow-injection analysis methodology. In addition, we demonstrate the rapid determination of homovanillic acid and 5-hydroxyindole-3-acetic acid in human urine – without the need for extraction procedures – using monolithic column chromatography with chemiluminescence detection.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier BV
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003195

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