The rapid analysis of heroin drug seizures using micellar electrokinetic chromatography with short-end injection

Anastos, Nicole, Lewis, Simon, Barnett, Neil, Pearson, James and Kirkbride, Paul 2005, The rapid analysis of heroin drug seizures using micellar electrokinetic chromatography with short-end injection, Journal of forensic sciences, vol. 50, no. 1, pp. 37-42.

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Title The rapid analysis of heroin drug seizures using micellar electrokinetic chromatography with short-end injection
Author(s) Anastos, Nicole
Lewis, Simon
Barnett, Neil
Pearson, James
Kirkbride, Paul
Journal name Journal of forensic sciences
Volume number 50
Issue number 1
Start page 37
End page 42
Publisher American Society for Testing and Materials
Place of publication West Conshohocken, Pa.
Publication date 2005-01
ISSN 0022-1198
1556-4029
Keyword(s) forensic science
heroin seizures
micellar electrokinetic chromatography
short-end injection
Summary A simple and rapid method for the analysis of heroin seizures by micellar electrokinetic chromatography with short-end injection is described. Separations were performed using an uncoated fused silica capillary, 50 cm×50 mm I.D.×360 mm O.D. with an effective separation length of 8 cm. The system was run at 25°C with an applied negative voltage of –25 kilovolts. Injection of each sample was for 2 s at –50 mbar. UV detection was employed with the wavelength set at 210 nm. The background electrolyte consisted of 85:15 (water:acetonitrile, v/v) containing final concentrations of 25 mM SDS and 15 mM sodium borate, pH 9.5. Samples and standards were prepared in 0.1% v/v acetic acid and diluted in the run buffer containing 1 mg/ml of N,N-dimethyl-5-methoxytryptamine as an internal standard. Under these conditions a text mixture containing caffeine, paracetamol, morphine, codeine, heroin, and acetylcodeine was resolved within 1.5 min. The method was used to determine the concentration of heroin in heroin seizure samples, and the results were in good agreement with those obtained by a validated gas chromatographic method.
Language eng
Field of Research 030108 Separation Science
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, American Society for Testing and Materials
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003200

Document type: Journal Article
Collection: School of Biological and Chemical Sciences
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