A rapid test for heroin (3,6-Diacetylmorphine) based on two chemiluminescence reactions

Agg, Kent, Craddock, Adrian, Bos, Richard, Francis, Paul, Lewis, Simon and Barnett, Neil 2006, A rapid test for heroin (3,6-Diacetylmorphine) based on two chemiluminescence reactions, Journal of forensic sciences, vol. 51, no. 5, pp. 1080-1084.

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Title A rapid test for heroin (3,6-Diacetylmorphine) based on two chemiluminescence reactions
Author(s) Agg, Kent
Craddock, Adrian
Bos, Richard
Francis, Paul
Lewis, Simon
Barnett, Neil
Journal name Journal of forensic sciences
Volume number 51
Issue number 5
Start page 1080
End page 1084
Publisher American Society for Testing and Materials
Place of publication West Conshohocken, Pa
Publication date 2006-08
ISSN 0022-1198
1556-4029
Keyword(s) forensic science
forensic chemistry
chemiluminescence
drug screening
presumptive chemical test
spot test
heroin
3,6-diacetylmorphine
morphine
Summary A rapid method for screening drug seizure samples for 3,6-diacetylmorphine (heroin), which consists of a simple hydrolysis procedure and flow-injection analysis with two chemiluminescence reagents, is described. Before hydrolysis, 3,6-diacetylmorphine evokes an intense response with a tris(2,2'-bipyridyl)ruthenium(III) reagent (prepared by dissolving the perchlorate salt in acetonitrile), and a relatively weak chemiluminescence response with a second reagent: potassium permanganate in an aqueous acidic polyphosphate solution. However, the permanganate reagent is extremely sensitive toward the hydrolysis products of 3,6-diacetylmorphine (i.e., 6-monoacetylmorphine and morphine). Some compounds commonly found in drug laboratories may cause false positives with tris(2,2'-bipyridyl)ruthenium(III), but do not produce the markedly increased response with the permanganate reagent after the hydrolysis procedure. The combination of these two tests therefore provides an effective presumptive test for the presence of 3,6-diacetylmorphine, which we have verified with 14 samples obtained from a forensic science laboratory.
Language eng
Field of Research 030103 Flow Analysis
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, American Society for Testing and Materials
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003653

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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