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The effects of short-term sprint training on MCT expression in moderately endurance-trained runners

Bickham, Dale, Bentley, David, Le Rossignol, Peter and Cameron-Smith, David 2006, The effects of short-term sprint training on MCT expression in moderately endurance-trained runners, European journal of applied physiology, vol. 96, no. 6, pp. 636-643.

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Title The effects of short-term sprint training on MCT expression in moderately endurance-trained runners
Author(s) Bickham, Dale
Bentley, David
Le Rossignol, Peter
Cameron-Smith, David
Journal name European journal of applied physiology
Volume number 96
Issue number 6
Start page 636
End page 643
Publisher Springer-Verlag
Place of publication Heidelberg, Germany
Publication date 2006-04
ISSN 1439-6319
1439-6327
Keyword(s) Anaerobic
Running
Fiber type
Interval
Lactate transport
Summary The purpose of this study was to assess the effects of short-term sprint training on transient changes in monocarboxylate lactate transporter 1 (MCT1) and MCT4 protein and mRNA content. Seven moderately endurance-trained runners (mean ± SE; age 27.7±2.9 years, body mass 81.1±5.9 kg, VO2 max 58.1±2.0 ml kg−1 min−1) completed a VO2 max and a supramaximal running test to exhaustion (RTE) before and after a 6-week period of sprint training. The sprint training was progressive and consisted of 18 sessions of near maximal short duration (5–15 s) sprints to compliment the athlete’s endurance training. Prior to the training period there was a significant (P<0.05) increase in MCT1, but not MCT4 protein, 2 h after the RTE. This occurred without any change in corresponding mRNA levels. After the training period, there was a significant increase in MCT1 protein but no significant change in the MCT4 isoform. Both MCT1 and MCT4 mRNA was significantly lower at rest and 2 h post-RTE after the completion of the training period. After the training period, there was a significant increase in the time to exhaustion and distance covered during the RTE. This study demonstrates that sprint training of this length and type results in an upregulation of MCT1 protein, but not MCT4 content. Additionally, this study shows conflicting adaptations in MCT1 and MCT4 protein and mRNA levels following training, which may indicate post-transcriptional regulation of MCT expression in human muscle.
Language eng
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Springer-Verlag
Persistent URL http://hdl.handle.net/10536/DRO/DU:30003924

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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