Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.

Civitarese, Anthony E., Hesselink, Matthijs K. C., Russell, Aaron, Ravussin, Eric and Schrauwen, Patrick 2005, Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes., American journal of physiology: endocrinology and metabolism, vol. 289, no. 6, pp. 1023-1029.

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Title Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes.
Author(s) Civitarese, Anthony E.
Hesselink, Matthijs K. C.
Russell, Aaron
Ravussin, Eric
Schrauwen, Patrick
Journal name American journal of physiology: endocrinology and metabolism
Volume number 289
Issue number 6
Start page 1023
End page 1029
Publisher American Physiological Society
Place of publication Bethesda, Md.
Publication date 2005-07-19
ISSN 0193-1849
1522-1555
Keyword(s) skeletal muscle gene expression
exercise-diet interaction
Summary Ingestion of carbohydrate during exercise may blunt the stimulation of fat oxidative pathways by raising plasma insulin and glucose concentrations and lowering plasma free fatty acid (FFA) levels, thereby causing a marked shift in substrate oxidation. We investigated the effects of a single 2-h bout of moderate-intensity exercise on the expression of key genes involved in fat and carbohydrate metabolism with or without glucose ingestion in seven healthy untrained men (22.7 ± 0.6 yr; body mass index: 23.8 ± 1.0 kg/m2; maximal O2 consumption: 3.85 ± 0.21 l/min). Plasma FFA concentration increased during exercise (P < 0.01) in the fasted state but remained unchanged after glucose ingestion, whereas fat oxidation (indirect calorimetry) was higher in the fasted state vs. glucose feeding (P < 0.05). Except for a significant decrease in the expression of pyruvate dehydrogenase kinase-4 (P < 0.05), glucose ingestion during exercise produced minimal effects on the expression of genes involved in carbohydrate utilization. However, glucose ingestion resulted in a decrease in the expression of genes involved in fatty acid transport and oxidation (CD36, carnitine palmitoyltransferase-1, uncoupling protein 3, and 5'-AMP-activated protein kinase-α2; P < 0.05). In conclusion, glucose ingestion during exercise decreases the expression of genes involved in lipid metabolism rather than increasing genes involved in carbohydrate metabolism.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2005, American Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004097

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