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Antioxidants and basal cell carcinoma of the skin : a nested case-control study

McNaughton, Sarah, Marks, Geoffrey C., Gaffney, Philip, Williams, Gail and Green, Adele C. 2005, Antioxidants and basal cell carcinoma of the skin : a nested case-control study, Cancer causes and control, vol. 16, no. 5, pp. 609-618.

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Title Antioxidants and basal cell carcinoma of the skin : a nested case-control study
Author(s) McNaughton, Sarah
Marks, Geoffrey C.
Gaffney, Philip
Williams, Gail
Green, Adele C.
Journal name Cancer causes and control
Volume number 16
Issue number 5
Start page 609
End page 618
Publisher Springer Netherlands
Place of publication Delft, The Netherlands
Publication date 2005-06
ISSN 0957-5243
1573-7225
Keyword(s) skin cancer
diet
antioxidants
carotenoids
selenium
vitamin E
serum biomarkers
Summary Objective To investigate the relationship between basal cell carcinoma (BCC) and antioxidant nutrients, specifically carotenoids, vitamin E and selenium.

Methods The Nambour Skin Cancer Study is an ongoing, community-based study of randomly selected adult residents of a township in sub-tropical Queensland, Australia. Using a nested case–control design, incident cases of BCC (n=90) were compared with age and sex matched controls (n=90). Dietary exposure was measured using food frequency questionnaire estimates of intake as well as serum biomarkers. Other determinants of skin cancer including sun exposure were also considered. Dietary intakes were adjusted for energy intake, and serum carotenoids and vitamin E were adjusted for serum cholesterol. Odds ratios were calculated across quartiles of dietary intake and serum biomarkers and linear trends were assessed using logistic regression, adjusting for age, sex and supplement use.

Results and conclusions In this prospective study no significant associations were found between BCC and carotenoids, vitamin E or selenium, as measured by serum biomarkers or dietary intake, although there was a suggestion of a positive association with lutein intake.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004120

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