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Genetic albation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action

Molero, Juan, Turner, Nigel, Thien, Christine B. F., Langdon, Wallace Y., James, David E. and Cooney, Gregory J. 2006, Genetic albation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action, Diabetes, vol. 55, pp. 3411-3417, doi: 10.2337/db06-0955.

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Title Genetic albation of the c-Cbl ubiquitin ligase domain results in increased energy expenditure and improved insulin action
Author(s) Molero, Juan
Turner, Nigel
Thien, Christine B. F.
Langdon, Wallace Y.
James, David E.
Cooney, Gregory J.
Journal name Diabetes
Volume number 55
Start page 3411
End page 3417
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2006
ISSN 0012-1797
1939-327X
Summary Casitas b-lineage lymphoma (c-Cbl) is a multiadaptor protein with E3-ubiquitin ligase activity residing within its RING finger domain. We have previously reported that c-Cbl–deficient mice exhibit elevated energy expenditure, reduced adiposity, and improved insulin action. In this study, we examined mice expressing c-Cbl protein with a loss-of-function mutation within the RING finger domain (c-CblA/– mice). Compared with control animals, c-CblA/– mice display a phenotype that includes reduced adiposity, despite greater food intake; reduced circulating insulin, leptin, and triglyceride levels; and improved glucose tolerance. c-CblA/– mice also display elevated oxygen consumption (13%) and are protected against high-fat diet–induced obesity and insulin resistance. Unlike c-CblA/– mice, mice expressing a mutant c-Cbl with the phosphatidylinositol (PI) 3-kinase binding domain ablated (c-CblF/F mice) exhibited an insulin sensitivity, body composition, and energy expenditure similar to that of wild-type animals. These results indicate that c-Cbl ubiquitin ligase activity, but not c-Cbl–dependent activation of PI 3-kinase, plays a key role in the regulation of whole-body energy metabolism.
Language eng
DOI 10.2337/db06-0955
Field of Research 060603 Animal Physiology - Systems
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, American Diabetes Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004146

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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