Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells

Gao, Yuan, Hannan, Nicholas R. F., Wanyonyi, Stephen, Konstantopoulos, Nicky, Pagnon, Joanne, Feng, Helen C., Jowett, Jeremy B. M., Kim, Kee-Hong, Walder, Ken and Collier, Greg R. 2006, Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells, Cytokine, vol. 33, no. 5, pp. 246-251.

Attached Files
Name Description MIMEType Size Downloads

Title Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells
Author(s) Gao, Yuan
Hannan, Nicholas R. F.
Wanyonyi, Stephen
Konstantopoulos, Nicky
Pagnon, Joanne
Feng, Helen C.
Jowett, Jeremy B. M.
Kim, Kee-Hong
Walder, Ken
Collier, Greg R.
Journal name Cytokine
Volume number 33
Issue number 5
Start page 246
End page 251
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2006-03-07
ISSN 1043-4666
1096-0023
Keyword(s) selenoprotein
glucose-regulated protein
ER stress
cytokine
gene expression
Summary SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic reticulum (ER) stress. In this report, we have identified two binding sites for the nuclear factor kappa B in the human SEPS1 promoter. SEPS1 gene expression, protein levels and promoter activity were all increased 2–3-fold by TNF-α and IL-1β in HepG2 cells. We have also confirmed that the previously proposed ER stress response element GGATTTCTCCCCCGCCACG in the SEPS1 proximate promoter is fully functional and responsive to ER stress. However, concurrent treatment of HepG2 cells with IL-1β and ER stress produced no additive effect on SEPS1 gene expression. We conclude that SEPS1 is a new target gene of NF-κB. Together with our previous findings that SEPS1 may regulate cytokine production in macrophage cells, we propose a regulatory loop between cytokines and SEPS1 that plays a key role in control of the inflammatory response.
Language eng
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier Ltd
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004155

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 39 times in TR Web of Science
Scopus Citation Count Cited 38 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 462 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Mon, 07 Jul 2008, 09:13:36 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.