Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells

Gao, Yuan, Hannan, Nicholas R. F., Wanyonyi, Stephen, Konstantopoulos, Nicky, Pagnon, Joanne, Feng, Helen C., Jowett, Jeremy B. M., Kim, Kee-Hong, Walder, Ken and Collier, Greg R. 2006, Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells, Cytokine, vol. 33, no. 5, pp. 246-251, doi: 10.1016/j.cyto.2006.02.005.

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Title Activation of the selenopritein SEPS1 gene expression by pro-inflammatory cytokines in Hep G2 cells
Author(s) Gao, Yuan
Hannan, Nicholas R. F.
Wanyonyi, Stephen
Konstantopoulos, Nicky
Pagnon, Joanne
Feng, Helen C.
Jowett, Jeremy B. M.
Kim, Kee-Hong
Walder, KenORCID iD for Walder, Ken
Collier, Greg R.
Journal name Cytokine
Volume number 33
Issue number 5
Start page 246
End page 251
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2006-03-07
ISSN 1043-4666
Keyword(s) selenoprotein
glucose-regulated protein
ER stress
gene expression
Summary SEPS1 (also called selenoprotein S, SelS) plays an important role in the production of inflammatory cytokines and its expression is activated by endoplasmic reticulum (ER) stress. In this report, we have identified two binding sites for the nuclear factor kappa B in the human SEPS1 promoter. SEPS1 gene expression, protein levels and promoter activity were all increased 2–3-fold by TNF-α and IL-1β in HepG2 cells. We have also confirmed that the previously proposed ER stress response element GGATTTCTCCCCCGCCACG in the SEPS1 proximate promoter is fully functional and responsive to ER stress. However, concurrent treatment of HepG2 cells with IL-1β and ER stress produced no additive effect on SEPS1 gene expression. We conclude that SEPS1 is a new target gene of NF-κB. Together with our previous findings that SEPS1 may regulate cytokine production in macrophage cells, we propose a regulatory loop between cytokines and SEPS1 that plays a key role in control of the inflammatory response.
Language eng
DOI 10.1016/j.cyto.2006.02.005
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2006, Elsevier Ltd
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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