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A perspective on the role of natriuretic peptides in amphibian osmoregulation

Donald, John and Trajanovska, Sofie 2006, A perspective on the role of natriuretic peptides in amphibian osmoregulation, General and comparative endocrinology, vol. 147, no. 1, pp. 47-53, doi: 10.1016/j.ygcen.2005.10.012.

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Title A perspective on the role of natriuretic peptides in amphibian osmoregulation
Author(s) Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Trajanovska, Sofie
Journal name General and comparative endocrinology
Volume number 147
Issue number 1
Start page 47
End page 53
Publisher Elsevier
Place of publication Amsterdam, Netherlands
Publication date 2006-05-15
ISSN 0016-6480
1095-6840
Keyword(s) natriuretic peptide
natriuretic peptide receptor
amphibian
osmoregulation
cardiovascular regulation
kidney
Summary The natriuretic peptide (NP) system is a complex family of peptides and receptors that is primarily linked to the maintenance of osmotic and cardiovascular homeostasis. In amphibians, the potential role(s) of NPs is complicated by the range of osmoregulatory strategies found in amphibians, and the different tissues that participate in osmoregulation. Atrial NP, brain NP, and C-type NP have been isolated or cloned from a number of species, which has enabled physiological studies to be performed with homologous peptides. In addition, three types of NP receptors have been cloned and partially characterised. Natriuretic peptides are always potent vasodilators in amphibian blood vessels, and ANP has been shown to increase the permeability of the microcirculation. In the perfused kidney, ANP causes vasodilation, diuresis and natriuresis that are caused by an increased GFR rather than effects in the renal tubules. These data are supported by the presence of ANP receptors only on the glomeruli and renal blood vessels. In the bladder and skin, the function of NPs is enigmatic because physiological analysis of the effects of ANP on bladder and skin function has yielded conflicting data with no clear role for NPs being revealed. Overall, NPs often have no direct effect, but in some studies they have been shown to inhibit the function of AVT. In addition, there is evidence that ANP can inhibit salt retention in amphibians since it can inhibit the ability of adrenocorticotrophic hormone or angiotensin II to stimulate corticosteroid secretion. It is proposed that an important role for cardiac NPs could be in the control of hypervolaemia during periods of rapid rehydration, which occurs in terrestrial amphibians.
Language eng
DOI 10.1016/j.ygcen.2005.10.012
Field of Research 060604 Comparative Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004163

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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