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The response of the natriuretic peptide system to water deprivation in the desert rodent, Notomys alexis

Heimeier, Rachel A. and Donald, John 2006, The response of the natriuretic peptide system to water deprivation in the desert rodent, Notomys alexis, Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, vol. 143, no. 2, pp. 193-201, doi: 10.1016/j.cbpa.2005.11.018.

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Title The response of the natriuretic peptide system to water deprivation in the desert rodent, Notomys alexis
Author(s) Heimeier, Rachel A.
Donald, JohnORCID iD for Donald, John orcid.org/0000-0001-5930-2642
Journal name Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Volume number 143
Issue number 2
Start page 193
End page 201
Publisher Elsevier
Place of publication New York, N.Y.
Publication date 2006-02
ISSN 1095-6433
1531-4332
Keyword(s) atrial natriuretic peptide
C-type natriuretic peptide
natriuretic peptide receptor B
cGMP
mRNA expression
water deprivation
notomys alexis
kidney
Summary Natriuretic peptides (NPs) are regulatory molecules that cause cGMP-mediated diuresis and natriuresis in mammals. Accordingly, it is interesting to consider their role in desert-adapted animals in which water is often limited. This study investigated the response of the natriuretic peptide (NP) system to varying periods of water deprivation (WD) in the Australian desert rodent species, Notomys alexis. It was hypothesised that the expression of the NP system will be down-regulated in water-deprived N. alexis compared to water-replete animals. The plasma levels of ANP were significantly reduced after 3 days of WD, but were unaffected by 7, 14 and 28 days of WD. Water deprivation for 3, 7, 14 days had a variable effect on the mRNA expression of ANP, CNP, NPR-A, NPR-B, and NPR-C, and a uniform down-regulation was not observed. However, after 28 days of WD, mRNA expression was similar to water-replete animals, except for NPR-A. Surprisingly, 7 and 14 days of WD caused an up-regulation in the ability of ANP to stimulate cGMP; this also occurred at 14 days for CNP. Taken together, the mRNA expression and peptide mediated guanylyl cyclase activity data after WD were in the opposite direction to what was predicted. Interestingly, after 28 days of WD, most parameters were similar to those of water-replete animals, which indicates that a down-regulation of the NP system is not part of the physiological response to an absence of free water in N. alexis.
Language eng
DOI 10.1016/j.cbpa.2005.11.018
Field of Research 060604 Comparative Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier Inc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004164

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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