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Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?

Russell, Aaron, Gastaldi, Giacomo, Bobbioni-Harsch, Elisabetta, Arboit, Patrizia, Gobelet, Charles, Deriaz, Olivier, Golay, Alain, Witztum, Joseph L. and Giacobino, Jean-Paul 2003, Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?, FEBS letter, vol. 551, no. 1-3, pp. 104-106, doi: 10.1016/S0014-5793(03)00875-5.

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Title Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
Author(s) Russell, AaronORCID iD for Russell, Aaron orcid.org/0000-0002-7323-9501
Gastaldi, Giacomo
Bobbioni-Harsch, Elisabetta
Arboit, Patrizia
Gobelet, Charles
Deriaz, Olivier
Golay, Alain
Witztum, Joseph L.
Giacobino, Jean-Paul
Journal name FEBS letter
Volume number 551
Issue number 1-3
Start page 104
End page 106
Publisher Elsevier BV
Place of publication Amsterdam, The Netherlands
Publication date 2003-09-11
ISSN 0014-5793
1873-3468
Keyword(s) lipid peroxidation
muscle
obesity
endurance training
4-Hydroxynonenal
intra-myocellular triglyceride
Summary Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.


Language eng
DOI 10.1016/S0014-5793(03)00875-5
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Federation of European Biochemical Societies
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004195

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