Casitas b-lineage lymphoma-deficient mice are pretected against high-fat diet-induuced obesity and insulin resistance

Molero, Juan, Waring, Samuel, Cooper, Adrian, Laybutt, Ross, Turner, Nigel, Cooney, Gregory and James, David 2006, Casitas b-lineage lymphoma-deficient mice are pretected against high-fat diet-induuced obesity and insulin resistance, Diabetes, vol. 55, no. 3, pp. 708-715.

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Title Casitas b-lineage lymphoma-deficient mice are pretected against high-fat diet-induuced obesity and insulin resistance
Author(s) Molero, Juan
Waring, Samuel
Cooper, Adrian
Laybutt, Ross
Turner, Nigel
Cooney, Gregory
James, David
Journal name Diabetes
Volume number 55
Issue number 3
Start page 708
End page 715
Publisher American Diabetes Association
Place of publication New York, N.Y.
Publication date 2006-03
ISSN 0012-1797
1939-327X
Summary Casitas b-lineage lymphoma (c-Cbl) is a multiadaptor protein with E3-ubiquitin ligase activity involved in regulating the degradation of receptor tyrosine kinases. We have recently reported that c-Cbl–/– mice exhibit a lean phenotype and enhanced peripheral insulin action likely due to elevated energy expenditure. In the study reported here, we examined the effect of a high-fat diet on energy homeostasis and glucose metabolism in these animals. When c-Cbl–/– mice were fed a high-fat diet for 4 weeks, they maintained hyperphagia, higher whole-body oxygen consumption (27%), and greater activity (threefold) compared with wild-type animals fed the same diet. In addition, the activity of several enzymes involved in mitochondrial fat oxidation and the phosphorylation of acetyl CoA carboxylase was significantly increased in muscle of high-fat–fed c-Cbl–deficient mice, indicating a greater capacity for fat oxidation in these animals. As a result of these differences, fat-fed c-Cbl–/– mice were 30% leaner than wild-type animals and were protected against high-fat diet–induced insulin resistance. These studies are consistent with a role for c-Cbl in regulating nutrient partitioning in skeletal muscle and emphasize the potential of c-Cbl as a therapeutic target in the treatment of obesity and type 2 diabetes.
Language eng
Field of Research 060603 Animal Physiology - Systems
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2006, American Diabetes Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004247

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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