Health-related quality of life and metabolic control in children with type 1 diabetes : a prospective cohort study

Hesketh, Kylie, Wake, Melissa A. and Cameron, Fergus J. 2004, Health-related quality of life and metabolic control in children with type 1 diabetes : a prospective cohort study, Diabetes care, vol. 27, no. 2, pp. 415-420.

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Title Health-related quality of life and metabolic control in children with type 1 diabetes : a prospective cohort study
Author(s) Hesketh, KylieORCID iD for Hesketh, Kylie
Wake, Melissa A.
Cameron, Fergus J.
Journal name Diabetes care
Volume number 27
Issue number 2
Start page 415
End page 420
Publisher American Diabetes Association
Place of publication Alexandria, Va.
Publication date 2004-02
ISSN 0149-5992
Summary OBJECTIVE—To assess change in health-related quality of life (HRQOL) in children with diabetes over 2 years and determine its relationship to change in metabolic control.

RESEARCH DESIGN AND METHODS—In 1998, parents of children aged 5–18 years attending a tertiary diabetes clinic reported their child’s HRQOL using the Child Health Questionnaire PF-50. Those aged 12–18 years also self-reported their HRQOL using the analogous Child Health Questionnaire CF-80. HbA1c levels were recorded. In 2000, identical measures were collected for those who were aged ≤18 years and still attending the clinic.

—Of 117 eligible subjects, 83 (71%) participated. Parents reported no significant difference in children’s HRQOL at baseline and follow-up. However, adolescents reported significant improvements on the Family Activities (P < 0.001), Bodily Pain (P = 0.04), and General Health Perceptions (P = 0.001) scales and worsening on the Behavior (P = 0.04) scale. HbA1c at baseline and follow-up were strongly correlated (r = 0.57). HbA1c increased significantly (mean 7.8% in 1998 vs. 8.5% in 2000; P < 0.001), with lower baseline HbA1c strongly predicting an increase in HbA1c over the 2 years (r2 = 0.25, P < 0.001). Lower parent-reported Physical Summary and adolescent-reported Physical Functioning scores at baseline also predicted increasing HbA1c. Poorer parent-reported Psychosocial Summary scores were related to higher HbA1c at both times but did not predict change in HbA1c.

CONCLUSIONS—Changes in parent and adolescent reports of HRQOL differ. Better physical functioning may protect against deteriorating HbA1c, at least in the medium term. While the HRQOL of children with diabetes does not appear to deteriorate over time, we should not be complacent, as it is consistently poorer than that of their healthy peers.

Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004 by the American Diabetes Association
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