Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise

Russell, Aaron, Hesselink, Matthijs, Lo, Sing Kai and Schrauwen, Patrick 2005, Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise, The FASEB journal : official publication of the Federation of American Societies for experimental biology, vol. 19, no. 8, pp. 986-988.

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Title Regulation of metabolic transcriptional co-activators and transcription factors with acute exercise
Author(s) Russell, Aaron
Hesselink, Matthijs
Lo, Sing Kai
Schrauwen, Patrick
Journal name The FASEB journal : official publication of the Federation of American Societies for experimental biology
Volume number 19
Issue number 8
Start page 986
End page 988
Publisher Federation of American Societies for Experimental Biology
Place of publication Bethesda, Md.
Publication date 2005-06
ISSN 0892-6638
1530-6860
Keyword(s) PGC-1α
PPAR
SREBP-1c
FKHR
MCIP1
Summary Endurance exercise improves insulin sensitivity and increases fat oxidation, which are partly facilitated by the induction of metabolic transcription factors. Next to exercise, increased levels of FFA's also increase the gene expression of transcription factors, hence making it difficult to discern the effects from contractile signals produced during exercise, from those produced by increased circulatory FFA's. We aimed to investigate, in human skeletal muscle, whether acute exercise affects gene expression of metabolic transcriptional co-activators and transcription factors, including PGC-1α, PRC, PPARα, β/δ, and γ and RXR, SREBP-1c and FKHR, and to discern the effect of exercise per se from those of elevated levels of FFA. Two hours of endurance exercise was performed either in the fasted state, or following carbohydrate ingestion prior to and during exercise, thereby blunting the fasting-induced increase in FA availability and oxidation. Of the genes measured, PGC-1α and PRC mRNA increased immediately after, while PPARβ/δ and FKHR mRNA increased 1–4 h after exercise, irrespective of the increases in FFA's. Our results suggest that the induction in vivo of metabolic transcription factors implicated in mitochondrial biogenesis are under the control of inherent signals, (PGC-1α, PRC), while those implicated in substrate selection are under the control of associated signals (PPARβ/δ, FKHR) stimulated from the contracting skeletal muscle that are independent of circulating FFA levels.
Language eng
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, FASEB
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004275

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