The brachyspira hyodysenteriae ftnA gene : DNA vaccination and real-time PCR quantification of bacteria in a mouse model of disease

Davis, Antony J., Smith, Stuart and Moore, Robert J. 2005, The brachyspira hyodysenteriae ftnA gene : DNA vaccination and real-time PCR quantification of bacteria in a mouse model of disease, Current microbiology, vol. 50, no. 6, pp. 285-291.

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Title The brachyspira hyodysenteriae ftnA gene : DNA vaccination and real-time PCR quantification of bacteria in a mouse model of disease
Author(s) Davis, Antony J.
Smith, Stuart
Moore, Robert J.
Journal name Current microbiology
Volume number 50
Issue number 6
Start page 285
End page 291
Publisher Springer New York LLC
Place of publication New York, N.Y.
Publication date 2005-06
ISSN 0343-8651
1432-0991
Summary The nucleotide sequence of the Brachyspira hyodysenteriae ftnA gene, encoding a putative ferritin protein (FtnA), was determined. Analysis of the sequence predicted that this gene encoded a protein of 180 amino acids. RT-PCR and Western blot showed that the ftnA gene was expressed in B. hyodysenteriae, and evidence suggests that FtnA stores iron rather than haem. ftnA was delivered as DNA and recombinant protein vaccines in a mouse model of B. hyodysenteriae infection. Vaccine efficacy was monitored by caecal pathology and quantification of B. hyodysenteriae numbers in the caeca of infected mice by real-time PCR.
Language eng
Field of Research 060501 Bacteriology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Springer Science + Business Media Ιnc.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30006509

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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