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A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males

Kelly, F. D., Sinclair, Andrew, Mann, N. J., Turner, A. H., Abedin, L. and Li, D. 2001, A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males, European journal of clinical nutrition, vol. 55, no. 2, pp. 88-96.

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Title A stearic acid-rich diet improves thrombogenic and atherogenic risk factor profiles in healthy males
Author(s) Kelly, F. D.
Sinclair, Andrew
Mann, N. J.
Turner, A. H.
Abedin, L.
Li, D.
Journal name European journal of clinical nutrition
Volume number 55
Issue number 2
Start page 88
End page 96
Publisher Nature Publishing Group
Place of publication Basingstoke, England
Publication date 2001-02
ISSN 0954-3007
1476-5640
Keyword(s) stearic acid
palmitic acid
platelets
fatty acids
haemostatic factors
lipoproteins
platelet aggregation
mean platelet volume
Summary Objective: To determine whether healthy males who consumed increased amounts of dietary stearic acid compared with increased dietary palmitic acid exhibited any changes in their platelet aggregability, platelet fatty acid profiles, platelet morphology, or haemostatic factors.

Design: A randomized cross-over dietary intervention.

Subjects and interventions: Thirteen free-living healthy males consumed two experimental diets for 4 weeks with a 7 week washout between the two dietary periods. The diets consisted of ~30% of energy as fat (66% of which was the treatment fat) providing ~6.6% of energy as stearic acid (diet S) or ~7.8% of energy as palmitic acid (diet P). On days 0 and 28 of each dietary period, blood samples were collected and anthropometric and physiological measurements were recorded.

Results: Stearic acid was increased significantly in platelet phospholipids on diet S (by 22%), while on diet P palmitic acid levels in platelet phospholipids also increased significantly (8%). Mean platelet volume, coagulation factor FVII activity and plasma lipid concentrations were significantly decreased on diet S, while platelet aggregation was significantly increased on diet P.

Conclusion: Results from this study indicate that stearic acid (19 g/day) in the diet has beneficial effects on thrombogenic and atherogenic risk factors in males. The food industry might wish to consider the enrichment of foods with stearic acid in place of palmitic acid and trans fatty acids.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2001, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30006561

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Thu, 31 Jul 2008, 10:41:57 EST