Emerging host cell targets for hepatitis C therapy

He, Yupeng, Duan, Wei and Tan, Seng-Lai 2007, Emerging host cell targets for hepatitis C therapy, Drug discovery today, vol. 12, no. 5, pp. 209-217.

Title	Emerging host cell targets for hepatitis C therapy
Author(s)	He, Yupeng Duan, Wei Tan, Seng-Lai
Journal name	Drug discovery today
Volume number	12
Issue number	5
Start page	209
End page	217
Publisher	Elsevier Ltd.
Place of publication	Barking, England
Publication date	2007-03
ISSN	1359-6446
Summary	Chronic hepatitis C virus (HCV) infection is a major burden on humanity. The current HCV therapy has limited efficacy, and there is pressing need for new and more effective therapies. Host cell factors that are required for HCV infection, replication and/or pathogenesis represent potential therapeutic targets. Of particular interest are cellular receptors that mediate HCV entry, factors that facilitate HCV replication and assembly, and intracellular pathways involving lipid biosynthesis, oxidative stress and innate immune response. A crucial challenge now is to manipulate such cellular targets pharmacologically for chronic HCV treatment, without being limited by side effects.
Language	eng
Field of Research	110706 Immunogenetics (incl Genetic Immunology)
HERDC Research category	C1 Refereed article in a scholarly journal
Copyright notice	©2007, Elsevier Ltd.
Persistent URL	http://hdl.handle.net/10536/DRO/DU:30007091

Document type:	Journal Article
Collection:	School of Medicine

Citation counts:	Cited 18 times in TR Web of Science Cited 19 times in Scopus
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