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Maternal and neonatal influences on, and reproducibility of, neonatal aortic pulse wave velocity

Koudsi, Abir, Oldroyd, John, McElduff, Patrick, Banerjee, Moulinath, Vyas, Avni and Cruickshank, J. Kennedy 2007, Maternal and neonatal influences on, and reproducibility of, neonatal aortic pulse wave velocity, Hypertension, vol. 49, no. 1, pp. 225-231, doi: 10.1161/01.HYP.0000250434.73119.7a.

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Title Maternal and neonatal influences on, and reproducibility of, neonatal aortic pulse wave velocity
Author(s) Koudsi, Abir
Oldroyd, John
McElduff, Patrick
Banerjee, Moulinath
Vyas, Avni
Cruickshank, J. Kennedy
Journal name Hypertension
Volume number 49
Issue number 1
Start page 225
End page 231
Publisher Lippincott Williams & Wilkins
Place of publication Baltimore, Md.
Publication date 2007
ISSN 0194-911x
1524-4563
Keyword(s) aortic pulse wave velocity
neonatal
pregnancy
maternal blood pressure
birthweight
reproducibility
Summary Aortic pulse wave velocity (aPWV), a noninvasive measure of vascular stiffness, is an independent predictor of cardiovascular disease both before and in overt vascular disease. Its characteristics in early life and its relationship to maternal factors have hardly been studied. To test the hypothesis that infant aPWV was positively related to maternal anthropometry and blood pressure (BP) at 28 weeks gestation, after adjusting for neonatal anthropometry and BP, 148 babies born in Manchester were measured 1 to 3 days after birth. A high reproducibility of aPWV, assessed in 30 babies within 3 days of birth, was found with a mean difference between occasions of –0.04 m/s (95% CI: –0.08 to 0.16 m/s). Contrary to our hypothesis, a significant inverse relation was found between neonatal aPWV (mean: 4.6 m/s) and maternal systolic BP (mean: 108.9 mm Hg; r=–0.57; 95% CI: –0.67 to –0.45) but not maternal height nor weight. Neonatal aPWV was positively correlated with birth length, birth weight, and systolic BP. In multiple regression, neonatal aPWV remained significantly inversely associated with maternal systolic BP (adjusted ß coefficient: –0.032; 95% CI: –0.040 to –0.024; P<0.001), after adjustment for maternal age, birth weight, length, and neonatal BP (all independently and positively related to aPWV) and for gestational age, maternal weight, and height (unrelated). These results suggest that infant aPWV may be a useful index of infant vascular status, is less disturbing to measure than infant BP, and is sensitive to the gestational environment marked by maternal BP.
Language eng
DOI 10.1161/01.HYP.0000250434.73119.7a
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, American Heart Association
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007100

Document type: Journal Article
Collection: School of Health and Social Development
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