Chemerin is a novel adipokine associated with obesity and metabolic syndrome

Bozaoglu, Kiymet, Bolton, Kristy, McMillan, Janine, Zimmet, Paul, Jowett, Jeremy, Collier, Gregory, Walder, Ken and Segal, David 2007, Chemerin is a novel adipokine associated with obesity and metabolic syndrome, Endocrinology, vol. 148, no. 10, pp. 4687-4694, doi: 10.1210/en.2007-0175.

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Title Chemerin is a novel adipokine associated with obesity and metabolic syndrome
Author(s) Bozaoglu, Kiymet
Bolton, KristyORCID iD for Bolton, Kristy
McMillan, Janine
Zimmet, Paul
Jowett, Jeremy
Collier, Gregory
Walder, KenORCID iD for Walder, Ken
Segal, David
Journal name Endocrinology
Volume number 148
Issue number 10
Start page 4687
End page 4694
Publisher Association for the Study of Internal Secretions
Place of publication Los Angeles, Calif.
Publication date 2007-10
ISSN 0013-7227
Summary Soluble protein hormones are key regulators of a number of metabolic processes, including food intake and insulin sensitivity. We have used a signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model of obesity and type 2 diabetes (T2D). Using this signal sequence trap, we identified the chemokine chemerin as being a novel adipokine. Gene expression of chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher in adipose tissue of obese and type 2 diabetic P. obesus compared with lean, normoglycemic P. obesus. Fractionation of P. obesus adipose tissue confirmed that chemerin was predominantly expressed in adipocytes, whereas CMKLR1 was expressed in both adipocytes and stromal-vascular cells of adipose tissue. In 3T3-L1 adipocytes, chemerin was markedly induced during differentiation, whereas CMKLR1 was down-regulated during differentiation. Serum chemerin levels were measured by ELISA in human plasma samples from 114 subjects with T2D and 142 normal glucose tolerant controls. Plasma chemerin levels were not significantly different between subjects with T2D and normal controls. However, in normal glucose tolerant subjects, plasma chemerin levels were significantly associated with body mass index, circulating triglycerides, and blood pressure. Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome.
Language eng
DOI 10.1210/en.2007-0175
Field of Research 110306 Endocrinology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, The Endocrine Society
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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