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Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression

Hugo, Honor, Ackland, Leigh, Blick, Tony, Lawrence, Mitchell, Clements, Judith, Williams, Elizabeth and Thompson, Erik 2007, Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression, Journal of cellular physiology, vol. 213, no. 2, pp. 374-383, doi: 10.1002/jcp.21223.

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Title Epithelial - mesenchymal and mesenchymal - epithelial transitions in carcinoma progression
Author(s) Hugo, Honor
Ackland, LeighORCID iD for Ackland, Leigh orcid.org/0000-0002-7474-6556
Blick, Tony
Lawrence, Mitchell
Clements, Judith
Williams, Elizabeth
Thompson, Erik
Journal name Journal of cellular physiology
Volume number 213
Issue number 2
Start page 374
End page 383
Publisher Alan R. Liss
Place of publication New York, N.Y.
Publication date 2007-11
ISSN 0021-9541
1097-4652
Keyword(s) epithelial to mesenchymal transition
EMT
Summary Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life mirror those of one of the most common cause of death--metastatic cancer. Epithelial to mesenchymal transition (EMT) is an important change in cell phenotype which allows the escape of epithelial cells from the structural constraints imposed by tissue architecture, and was first recognized by Elizabeth Hay in the early to mid 1980's to be a central process in early embryonic morphogenesis. Reversals of these changes, termed mesenchymal to epithelial transitions (METs), also occur and are important in tissue construction in normal development. Over the last decade, evidence has mounted for EMT as the means through which solid tissue epithelial cancers invade and metastasize. However, demonstrating this potentially rapid and transient process in vivo has proven difficult and data connecting the relevance of this process to tumor progression is still somewhat limited and controversial. Evidence for an important role of MET in the development of clinically overt metastases is starting to accumulate, and model systems have been developed. This review details recent advances in the knowledge of EMT as it occurs in breast development and carcinoma and prostate cancer progression, and highlights the role that MET plays in cancer metastasis. Finally, perspectives from a clinical and translational viewpoint are discussed.
Language eng
DOI 10.1002/jcp.21223
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Wiley-Liss
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007175

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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